Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction

Brown bowel syndrome (BBS) is an exceedingly rare condition usually associated with longstanding malabsorption of any etiology. As a result of vitamin E deficiency and subsequent mitochondrial degeneration due to oxidative stress induced by free radicals, lipofuscin granules accumulate in the smooth...

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Autores principales:	Adnan Alkurdi, Diana Rubin, Alexander Seelhoff, Hermann Herbst
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	brown bowel syndrome lipofuscinosis pseudo-obstruction vitamin e deficiency Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/d7d88ef7d34045aa8b15796b9b247f0b
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spelling	oai:doaj.org-article:d7d88ef7d34045aa8b15796b9b247f0b2021-12-02T12:40:22ZBrown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction1662-063110.1159/000519942https://doaj.org/article/d7d88ef7d34045aa8b15796b9b247f0b2021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/519942https://doaj.org/toc/1662-0631Brown bowel syndrome (BBS) is an exceedingly rare condition usually associated with longstanding malabsorption of any etiology. As a result of vitamin E deficiency and subsequent mitochondrial degeneration due to oxidative stress induced by free radicals, lipofuscin granules accumulate in the smooth muscles of the gastrointestinal tract resulting in myopathy and dysmotility with underlying disease aggravation. The current study reports a BBS case in a 64-year-old female patient who had undergone jejunoileal bypass surgery as a bariatric procedure. The patient was admitted with signs of malabsorption and ileus in computed tomography imaging. Endoscopic workup revealed no stenosis or obstruction. The colon histologically showed periodic acid-Schiff-positive lipofuscin granules in the lamina muscularis mucosa consistent with BBS. The vitamin E level in the patient was extremely low. Moreover, clinical improvement was documented following high-dose substitution. BBS should be considered in patients with malabsorption of any cause especially with signs of gastrointestinal dysmotility. Vitamin E substitution may improve clinical status and prevent further deterioration.Adnan AlkurdiDiana RubinAlexander SeelhoffHermann HerbstKarger Publishersarticlebrown bowel syndromelipofuscinosispseudo-obstructionvitamin e deficiencyDiseases of the digestive system. GastroenterologyRC799-869ENCase Reports in Gastroenterology, Vol 15, Iss 3, Pp 960-965 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brown bowel syndrome lipofuscinosis pseudo-obstruction vitamin e deficiency Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	brown bowel syndrome lipofuscinosis pseudo-obstruction vitamin e deficiency Diseases of the digestive system. Gastroenterology RC799-869 Adnan Alkurdi Diana Rubin Alexander Seelhoff Hermann Herbst Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction
description	Brown bowel syndrome (BBS) is an exceedingly rare condition usually associated with longstanding malabsorption of any etiology. As a result of vitamin E deficiency and subsequent mitochondrial degeneration due to oxidative stress induced by free radicals, lipofuscin granules accumulate in the smooth muscles of the gastrointestinal tract resulting in myopathy and dysmotility with underlying disease aggravation. The current study reports a BBS case in a 64-year-old female patient who had undergone jejunoileal bypass surgery as a bariatric procedure. The patient was admitted with signs of malabsorption and ileus in computed tomography imaging. Endoscopic workup revealed no stenosis or obstruction. The colon histologically showed periodic acid-Schiff-positive lipofuscin granules in the lamina muscularis mucosa consistent with BBS. The vitamin E level in the patient was extremely low. Moreover, clinical improvement was documented following high-dose substitution. BBS should be considered in patients with malabsorption of any cause especially with signs of gastrointestinal dysmotility. Vitamin E substitution may improve clinical status and prevent further deterioration.
format	article
author	Adnan Alkurdi Diana Rubin Alexander Seelhoff Hermann Herbst
author_facet	Adnan Alkurdi Diana Rubin Alexander Seelhoff Hermann Herbst
author_sort	Adnan Alkurdi
title	Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction
title_short	Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction
title_full	Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction
title_fullStr	Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction
title_full_unstemmed	Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction
title_sort	brown bowel syndrome: an exceedingly rare condition with longstanding malabsorption and an unusual cause of colon pseudo-obstruction
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/d7d88ef7d34045aa8b15796b9b247f0b
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Brown Bowel Syndrome: An Exceedingly Rare Condition with Longstanding Malabsorption and an Unusual Cause of Colon Pseudo-Obstruction

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