Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family

Abstract Basic helix-loop-helix (bHLH) proteins, which are characterized by a conserved bHLH domain, comprise one of the largest families of transcription factors in both plants and animals, and have been shown to have a wide range of biological functions. However, there have been very few studies o...

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Autores principales:	Jinhua Yang, Min Gao, Li Huang, Yaqiong Wang, Steve van Nocker, Ran Wan, Chunlei Guo, Xiping Wang, Hua Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7dd2efbe10c44fd8a10506ba71f5d0a
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spelling	oai:doaj.org-article:d7dd2efbe10c44fd8a10506ba71f5d0a2021-12-02T11:53:04ZIdentification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family10.1038/s41598-017-00040-y2045-2322https://doaj.org/article/d7dd2efbe10c44fd8a10506ba71f5d0a2017-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00040-yhttps://doaj.org/toc/2045-2322Abstract Basic helix-loop-helix (bHLH) proteins, which are characterized by a conserved bHLH domain, comprise one of the largest families of transcription factors in both plants and animals, and have been shown to have a wide range of biological functions. However, there have been very few studies of bHLH proteins from perennial tree species. We describe here the identification and characterization of 175 bHLH transcription factors from apple (Malus × domestica). Phylogenetic analysis of apple bHLH (MdbHLH) genes and their Arabidopsis thaliana (Arabidopsis) orthologs indicated that they can be classified into 23 subgroups. Moreover, integrated synteny analysis suggested that the large-scale expansion of the bHLH transcription factor family occurred before the divergence of apple and Arabidopsis. An analysis of the exon/intron structure and protein domains was conducted to suggest their functional roles. Finally, we observed that MdbHLH subgroup III and IV genes displayed diverse expression profiles in various organs, as well as in response to abiotic stresses and various hormone treatments. Taken together, these data provide new information regarding the composition and diversity of the apple bHLH transcription factor family that will provide a platform for future targeted functional characterization.Jinhua YangMin GaoLi HuangYaqiong WangSteve van NockerRan WanChunlei GuoXiping WangHua GaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinhua Yang Min Gao Li Huang Yaqiong Wang Steve van Nocker Ran Wan Chunlei Guo Xiping Wang Hua Gao Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family
description	Abstract Basic helix-loop-helix (bHLH) proteins, which are characterized by a conserved bHLH domain, comprise one of the largest families of transcription factors in both plants and animals, and have been shown to have a wide range of biological functions. However, there have been very few studies of bHLH proteins from perennial tree species. We describe here the identification and characterization of 175 bHLH transcription factors from apple (Malus × domestica). Phylogenetic analysis of apple bHLH (MdbHLH) genes and their Arabidopsis thaliana (Arabidopsis) orthologs indicated that they can be classified into 23 subgroups. Moreover, integrated synteny analysis suggested that the large-scale expansion of the bHLH transcription factor family occurred before the divergence of apple and Arabidopsis. An analysis of the exon/intron structure and protein domains was conducted to suggest their functional roles. Finally, we observed that MdbHLH subgroup III and IV genes displayed diverse expression profiles in various organs, as well as in response to abiotic stresses and various hormone treatments. Taken together, these data provide new information regarding the composition and diversity of the apple bHLH transcription factor family that will provide a platform for future targeted functional characterization.
format	article
author	Jinhua Yang Min Gao Li Huang Yaqiong Wang Steve van Nocker Ran Wan Chunlei Guo Xiping Wang Hua Gao
author_facet	Jinhua Yang Min Gao Li Huang Yaqiong Wang Steve van Nocker Ran Wan Chunlei Guo Xiping Wang Hua Gao
author_sort	Jinhua Yang
title	Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family
title_short	Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family
title_full	Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family
title_fullStr	Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family
title_full_unstemmed	Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family
title_sort	identification and expression analysis of the apple (malus × domestica) basic helix-loop-helix transcription factor family
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d7dd2efbe10c44fd8a10506ba71f5d0a
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Identification and expression analysis of the apple (Malus × domestica) basic helix-loop-helix transcription factor family

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