Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.

The potential role of wild birds as carriers of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 is still a matter of debate. Consecutive or simultaneous infections with different subtypes of influenza viruses of low pathogenicity (LPAIV) are very common in wild duck populations. To bett...

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Autores principales:	Sasan R Fereidouni, Elke Starick, Martin Beer, Hendrik Wilking, Donata Kalthoff, Christian Grund, Rafaela Häuslaigner, Angele Breithaupt, Elke Lange, Timm C Harder
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7dd6a8375ad45cdb10f3230c8f4898f
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spelling	oai:doaj.org-article:d7dd6a8375ad45cdb10f3230c8f4898f2021-11-25T06:20:54ZHighly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.1932-620310.1371/journal.pone.0006706https://doaj.org/article/d7dd6a8375ad45cdb10f3230c8f4898f2009-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19693268/?tool=EBIhttps://doaj.org/toc/1932-6203The potential role of wild birds as carriers of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 is still a matter of debate. Consecutive or simultaneous infections with different subtypes of influenza viruses of low pathogenicity (LPAIV) are very common in wild duck populations. To better understand the epidemiology and pathogenesis of HPAIV H5N1 infections in natural ecosystems, we investigated the influence of prior infection of mallards with homo- (H5N2) and heterosubtypic (H4N6) LPAIV on exposure to HPAIV H5N1. In mallards with homosubtypic immunity induced by LPAIV infection, clinical disease was absent and shedding of HPAIV from respiratory and intestinal tracts was grossly reduced compared to the heterosubtypic and control groups (mean GEC/100 microl at 3 dpi: 3.0 x 10(2) vs. 2.3 x 10(4) vs. 8.7 x 10(4); p<0.05). Heterosubtypic immunity induced by an H4N6 infection mediated a similar but less pronounced effect. We conclude that the epidemiology of HPAIV H5N1 in mallards and probably other aquatic wild bird species is massively influenced by interfering immunity induced by prior homo- and heterosubtypic LPAIV infections.Sasan R FereidouniElke StarickMartin BeerHendrik WilkingDonata KalthoffChristian GrundRafaela HäuslaignerAngele BreithauptElke LangeTimm C HarderPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 4, Iss 8, p e6706 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sasan R Fereidouni Elke Starick Martin Beer Hendrik Wilking Donata Kalthoff Christian Grund Rafaela Häuslaigner Angele Breithaupt Elke Lange Timm C Harder Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.
description	The potential role of wild birds as carriers of highly pathogenic avian influenza virus (HPAIV) subtype H5N1 is still a matter of debate. Consecutive or simultaneous infections with different subtypes of influenza viruses of low pathogenicity (LPAIV) are very common in wild duck populations. To better understand the epidemiology and pathogenesis of HPAIV H5N1 infections in natural ecosystems, we investigated the influence of prior infection of mallards with homo- (H5N2) and heterosubtypic (H4N6) LPAIV on exposure to HPAIV H5N1. In mallards with homosubtypic immunity induced by LPAIV infection, clinical disease was absent and shedding of HPAIV from respiratory and intestinal tracts was grossly reduced compared to the heterosubtypic and control groups (mean GEC/100 microl at 3 dpi: 3.0 x 10(2) vs. 2.3 x 10(4) vs. 8.7 x 10(4); p<0.05). Heterosubtypic immunity induced by an H4N6 infection mediated a similar but less pronounced effect. We conclude that the epidemiology of HPAIV H5N1 in mallards and probably other aquatic wild bird species is massively influenced by interfering immunity induced by prior homo- and heterosubtypic LPAIV infections.
format	article
author	Sasan R Fereidouni Elke Starick Martin Beer Hendrik Wilking Donata Kalthoff Christian Grund Rafaela Häuslaigner Angele Breithaupt Elke Lange Timm C Harder
author_facet	Sasan R Fereidouni Elke Starick Martin Beer Hendrik Wilking Donata Kalthoff Christian Grund Rafaela Häuslaigner Angele Breithaupt Elke Lange Timm C Harder
author_sort	Sasan R Fereidouni
title	Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.
title_short	Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.
title_full	Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.
title_fullStr	Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.
title_full_unstemmed	Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.
title_sort	highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/d7dd6a8375ad45cdb10f3230c8f4898f
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Highly pathogenic avian influenza virus infection of mallards with homo- and heterosubtypic immunity induced by low pathogenic avian influenza viruses.

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