Nuclear factor kappa-B contributes to cigarette smoke tolerance in pancreatic ductal adenocarcinoma through cysteine metabolism

Nuclear factor kappa-B contributes to cigarette smoke tolerance in pancreatic ductal adenocarcinoma through cysteine metabolism

Background: Retrospective studies revealed that cigarette smoking enhances risk of incidence and worsens prognosis in pancreatic cancer (PC) patients. Poor prognosis in smoker cohort of PC patients indicates prevalence of cigarette smoke stimulated survival mechanisms yet to be explored in PC. In th...

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Main Authors: Venugopal Gunda, Yashpal S. Chhonker, Nagabhishek Sirpu Natesh, Pratima Raut, Sakthivel Muniyan, Todd A. Wyatt, Daryl J. Murry, Surinder K. Batra, Satyanarayana Rachagani
Format: article
Language:EN
Published: Elsevier 2021
Subjects:
pancreatic cancer
cigarette smoke
NF-κB
cysteine
glutathione
Therapeutics. Pharmacology
RM1-950
Online Access:https://doaj.org/article/d7e4aad8b04c4f4bb13a6c3b63a48cdf
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https://doaj.org/article/d7e4aad8b04c4f4bb13a6c3b63a48cdf

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