Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2
Abstract Early reperfusion after endovascular thrombectomy is associated with an improved outcome in ischemic stroke patients; however, the time dependency in elderly patients remains unclear. We investigated the time–outcome relationships in different age subgroups. Of 2420 patients enrolled in the...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/d7e8548878ed47d19a6a6b2d79f1097a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:d7e8548878ed47d19a6a6b2d79f1097a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:d7e8548878ed47d19a6a6b2d79f1097a2021-12-02T16:04:36ZTime–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 210.1038/s41598-021-92100-72045-2322https://doaj.org/article/d7e8548878ed47d19a6a6b2d79f1097a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92100-7https://doaj.org/toc/2045-2322Abstract Early reperfusion after endovascular thrombectomy is associated with an improved outcome in ischemic stroke patients; however, the time dependency in elderly patients remains unclear. We investigated the time–outcome relationships in different age subgroups. Of 2420 patients enrolled in the RESCUE-Japan Registry 2 study, a study based on a prospective registry of stroke patients with acute cerebral large-vessel occlusion at 46 centers, we analyzed the data of 1010 patients with successful reperfusion after endovascular therapy (mTICI of 2b or 3). In 3 age subgroups (< 70, 70 to < 80, and ≥ 80 years), the mRS scores at 90 days were analyzed according to 4 categories of onset-to-reperfusion time (< 180, 180 to < 240, 240 to < 300, and ≥ 300 min). In each age subgroup, the distributions of mRS scores were better with shorter onset-to-reperfusion times. The adjusted common odds ratios for better outcomes per 1-category delay in onset-to-reperfusion time were 0.66 (95% CI 0.55–0.80) in ages < 70 years, 0.66 (95% CI 0.56–0.79) in ages 70 to < 80 years, and 0.83 (95% CI 0.70–0.98) in ages ≥ 80 years. Early reperfusion was associated with better outcomes across all age subgroups. Achieving early successful reperfusion is important even in elderly patients.Kenichi TodoShinichi YoshimuraKazutaka UchidaHiroshi YamagamiNobuyuki SakaiHaruhiko KishimaHideki MochizukiMasayuki EzuraYasushi OkadaKazuo KitagawaKazumi KimuraMakoto SasakiNorio TanahashiKazunori ToyodaEisuke FuruiYuji MatsumaruKazuo MinematsuTakaya KitanoShuhei OkazakiTsutomu SasakiManabu SakaguchiMasatoshi TakagakiTakeo NishidaHajime NakamuraTakeshi MorimotoRESCUE-Japan Registry 2 InvestigatorsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Kenichi Todo Shinichi Yoshimura Kazutaka Uchida Hiroshi Yamagami Nobuyuki Sakai Haruhiko Kishima Hideki Mochizuki Masayuki Ezura Yasushi Okada Kazuo Kitagawa Kazumi Kimura Makoto Sasaki Norio Tanahashi Kazunori Toyoda Eisuke Furui Yuji Matsumaru Kazuo Minematsu Takaya Kitano Shuhei Okazaki Tsutomu Sasaki Manabu Sakaguchi Masatoshi Takagaki Takeo Nishida Hajime Nakamura Takeshi Morimoto RESCUE-Japan Registry 2 Investigators Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 |
| description |
Abstract Early reperfusion after endovascular thrombectomy is associated with an improved outcome in ischemic stroke patients; however, the time dependency in elderly patients remains unclear. We investigated the time–outcome relationships in different age subgroups. Of 2420 patients enrolled in the RESCUE-Japan Registry 2 study, a study based on a prospective registry of stroke patients with acute cerebral large-vessel occlusion at 46 centers, we analyzed the data of 1010 patients with successful reperfusion after endovascular therapy (mTICI of 2b or 3). In 3 age subgroups (< 70, 70 to < 80, and ≥ 80 years), the mRS scores at 90 days were analyzed according to 4 categories of onset-to-reperfusion time (< 180, 180 to < 240, 240 to < 300, and ≥ 300 min). In each age subgroup, the distributions of mRS scores were better with shorter onset-to-reperfusion times. The adjusted common odds ratios for better outcomes per 1-category delay in onset-to-reperfusion time were 0.66 (95% CI 0.55–0.80) in ages < 70 years, 0.66 (95% CI 0.56–0.79) in ages 70 to < 80 years, and 0.83 (95% CI 0.70–0.98) in ages ≥ 80 years. Early reperfusion was associated with better outcomes across all age subgroups. Achieving early successful reperfusion is important even in elderly patients. |
| format |
article |
| author |
Kenichi Todo Shinichi Yoshimura Kazutaka Uchida Hiroshi Yamagami Nobuyuki Sakai Haruhiko Kishima Hideki Mochizuki Masayuki Ezura Yasushi Okada Kazuo Kitagawa Kazumi Kimura Makoto Sasaki Norio Tanahashi Kazunori Toyoda Eisuke Furui Yuji Matsumaru Kazuo Minematsu Takaya Kitano Shuhei Okazaki Tsutomu Sasaki Manabu Sakaguchi Masatoshi Takagaki Takeo Nishida Hajime Nakamura Takeshi Morimoto RESCUE-Japan Registry 2 Investigators |
| author_facet |
Kenichi Todo Shinichi Yoshimura Kazutaka Uchida Hiroshi Yamagami Nobuyuki Sakai Haruhiko Kishima Hideki Mochizuki Masayuki Ezura Yasushi Okada Kazuo Kitagawa Kazumi Kimura Makoto Sasaki Norio Tanahashi Kazunori Toyoda Eisuke Furui Yuji Matsumaru Kazuo Minematsu Takaya Kitano Shuhei Okazaki Tsutomu Sasaki Manabu Sakaguchi Masatoshi Takagaki Takeo Nishida Hajime Nakamura Takeshi Morimoto RESCUE-Japan Registry 2 Investigators |
| author_sort |
Kenichi Todo |
| title |
Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 |
| title_short |
Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 |
| title_full |
Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 |
| title_fullStr |
Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 |
| title_full_unstemmed |
Time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of RESCUE-Japan Registry 2 |
| title_sort |
time–outcome relationship in acute large-vessel occlusion exists across all ages: subanalysis of rescue-japan registry 2 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d7e8548878ed47d19a6a6b2d79f1097a |
| work_keys_str_mv |
AT kenichitodo timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT shinichiyoshimura timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT kazutakauchida timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT hiroshiyamagami timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT nobuyukisakai timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT haruhikokishima timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT hidekimochizuki timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT masayukiezura timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT yasushiokada timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT kazuokitagawa timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT kazumikimura timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT makotosasaki timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT noriotanahashi timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT kazunoritoyoda timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT eisukefurui timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT yujimatsumaru timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT kazuominematsu timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT takayakitano timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT shuheiokazaki timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT tsutomusasaki timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT manabusakaguchi timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT masatoshitakagaki timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT takeonishida timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT hajimenakamura timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT takeshimorimoto timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 AT rescuejapanregistry2investigators timeoutcomerelationshipinacutelargevesselocclusionexistsacrossallagessubanalysisofrescuejapanregistry2 |
| _version_ |
1718385236810661888 |