miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells
Oxaliplatin resistance in colorectal cancers is a major clinical problem, and predictive markers are urgently needed. Here, the authors show that miR-625-3pexpression reduces the sensitivity of colorectal cancer cells to oxaliplatin by targeting the kinase MAP2K6, an activator of the MAPK14 pathway.
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Nature Portfolio
2016
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oai:doaj.org-article:d7e86a668ca54500aecfc5e9e097987c2021-12-02T17:33:20ZmiR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells10.1038/ncomms124362041-1723https://doaj.org/article/d7e86a668ca54500aecfc5e9e097987c2016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12436https://doaj.org/toc/2041-1723Oxaliplatin resistance in colorectal cancers is a major clinical problem, and predictive markers are urgently needed. Here, the authors show that miR-625-3pexpression reduces the sensitivity of colorectal cancer cells to oxaliplatin by targeting the kinase MAP2K6, an activator of the MAPK14 pathway.Mads Heilskov RasmussenIben LyskjærRosa Rakownikow Jersie-ChristensenLine Schmidt TarpgaardBjarke Primdal-BengtsonMorten Muhlig NielsenJakob Skou PedersenTine Plato HansenFlemming HansenJesper Velgaard OlsenPer PfeifferTorben Falck ØrntoftClaus Lindbjerg AndersenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016) |
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DOAJ |
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| topic |
Science Q |
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Science Q Mads Heilskov Rasmussen Iben Lyskjær Rosa Rakownikow Jersie-Christensen Line Schmidt Tarpgaard Bjarke Primdal-Bengtson Morten Muhlig Nielsen Jakob Skou Pedersen Tine Plato Hansen Flemming Hansen Jesper Velgaard Olsen Per Pfeiffer Torben Falck Ørntoft Claus Lindbjerg Andersen miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells |
| description |
Oxaliplatin resistance in colorectal cancers is a major clinical problem, and predictive markers are urgently needed. Here, the authors show that miR-625-3pexpression reduces the sensitivity of colorectal cancer cells to oxaliplatin by targeting the kinase MAP2K6, an activator of the MAPK14 pathway. |
| format |
article |
| author |
Mads Heilskov Rasmussen Iben Lyskjær Rosa Rakownikow Jersie-Christensen Line Schmidt Tarpgaard Bjarke Primdal-Bengtson Morten Muhlig Nielsen Jakob Skou Pedersen Tine Plato Hansen Flemming Hansen Jesper Velgaard Olsen Per Pfeiffer Torben Falck Ørntoft Claus Lindbjerg Andersen |
| author_facet |
Mads Heilskov Rasmussen Iben Lyskjær Rosa Rakownikow Jersie-Christensen Line Schmidt Tarpgaard Bjarke Primdal-Bengtson Morten Muhlig Nielsen Jakob Skou Pedersen Tine Plato Hansen Flemming Hansen Jesper Velgaard Olsen Per Pfeiffer Torben Falck Ørntoft Claus Lindbjerg Andersen |
| author_sort |
Mads Heilskov Rasmussen |
| title |
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells |
| title_short |
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells |
| title_full |
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells |
| title_fullStr |
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells |
| title_full_unstemmed |
miR-625-3p regulates oxaliplatin resistance by targeting MAP2K6-p38 signalling in human colorectal adenocarcinoma cells |
| title_sort |
mir-625-3p regulates oxaliplatin resistance by targeting map2k6-p38 signalling in human colorectal adenocarcinoma cells |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/d7e86a668ca54500aecfc5e9e097987c |
| work_keys_str_mv |
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