Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field

Abstract In this article, we highlight the alterations in the photoinduced electron transfer (ET) and hydrogen atom transfer (HAT) pathways between an anti-tumor drug vitamin-K3 (MQ) and a nucleobase adenine (ADN) in the presence of gold (Au) and iron (Fe) nanoparticles (NPs). Inside the confined mi...

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Autores principales:	Ranjan Kumar Behera, Abhishek Sau, Leepsa Mishra, Sankalan Mondal, Kallol Bera, Satish Kumar, Samita Basu, Manas Kumar Sarangi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7e8ce94ae024a209f3788102cad4f58
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spelling	oai:doaj.org-article:d7e8ce94ae024a209f3788102cad4f582021-12-02T15:09:32ZMetal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field10.1038/s41598-020-75262-82045-2322https://doaj.org/article/d7e8ce94ae024a209f3788102cad4f582020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-75262-8https://doaj.org/toc/2045-2322Abstract In this article, we highlight the alterations in the photoinduced electron transfer (ET) and hydrogen atom transfer (HAT) pathways between an anti-tumor drug vitamin-K3 (MQ) and a nucleobase adenine (ADN) in the presence of gold (Au) and iron (Fe) nanoparticles (NPs). Inside the confined micellar media, with laser flash photolysis corroborated with an external magnetic field (MF), we have detected the transient geminate radicals of MQ and ADN, photo-generated through ET and HAT. We observe that the presence of AuNP on the MQ-ADN complex (AuMQ-ADN) assists HAT by limiting the ET channel, on the other hand, FeNP on the MQ-ADN complex (FeMQ-ADN) mostly favors a facile PET. We hypothesize that through selective interactions of the ADN molecules with AuNP and MQ molecules with FeNP, a preferential HAT and PET process is eased. The enhanced HAT and PET have been confirmed by the escape yields of radical intermediates by time-resolved transient absorption spectroscopy in the presence of MF.Ranjan Kumar BeheraAbhishek SauLeepsa MishraSankalan MondalKallol BeraSatish KumarSamita BasuManas Kumar SarangiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ranjan Kumar Behera Abhishek Sau Leepsa Mishra Sankalan Mondal Kallol Bera Satish Kumar Samita Basu Manas Kumar Sarangi Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
description	Abstract In this article, we highlight the alterations in the photoinduced electron transfer (ET) and hydrogen atom transfer (HAT) pathways between an anti-tumor drug vitamin-K3 (MQ) and a nucleobase adenine (ADN) in the presence of gold (Au) and iron (Fe) nanoparticles (NPs). Inside the confined micellar media, with laser flash photolysis corroborated with an external magnetic field (MF), we have detected the transient geminate radicals of MQ and ADN, photo-generated through ET and HAT. We observe that the presence of AuNP on the MQ-ADN complex (AuMQ-ADN) assists HAT by limiting the ET channel, on the other hand, FeNP on the MQ-ADN complex (FeMQ-ADN) mostly favors a facile PET. We hypothesize that through selective interactions of the ADN molecules with AuNP and MQ molecules with FeNP, a preferential HAT and PET process is eased. The enhanced HAT and PET have been confirmed by the escape yields of radical intermediates by time-resolved transient absorption spectroscopy in the presence of MF.
format	article
author	Ranjan Kumar Behera Abhishek Sau Leepsa Mishra Sankalan Mondal Kallol Bera Satish Kumar Samita Basu Manas Kumar Sarangi
author_facet	Ranjan Kumar Behera Abhishek Sau Leepsa Mishra Sankalan Mondal Kallol Bera Satish Kumar Samita Basu Manas Kumar Sarangi
author_sort	Ranjan Kumar Behera
title	Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
title_short	Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
title_full	Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
title_fullStr	Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
title_full_unstemmed	Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field
title_sort	metal nanoparticle alters adenine induced charge transfer kinetics of vitamin k3 in magnetic field
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d7e8ce94ae024a209f3788102cad4f58
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Metal nanoparticle alters adenine induced charge transfer kinetics of vitamin K3 in magnetic field

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