HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

The molecular determinants of differential responses of different cancer cells to methionine restriction are poorly understood. Here the authors show that hepatocyte nuclear factor 4α regulates sulfur amino acid metabolism and dictates the sensitivity of liver cancer to this dietary manipulation.

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Autores principales:	Qing Xu, Yuanyuan Li, Xia Gao, Kai Kang, Jason G. Williams, Lingfeng Tong, Juan Liu, Ming Ji, Leesa J. Deterding, Xuemei Tong, Jason W. Locasale, Leping Li, Igor Shats, Xiaoling Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7e9ce8d5e534383a649d3e167e248f8
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spelling	oai:doaj.org-article:d7e9ce8d5e534383a649d3e167e248f82021-12-02T18:49:31ZHNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer10.1038/s41467-020-17818-w2041-1723https://doaj.org/article/d7e9ce8d5e534383a649d3e167e248f82020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17818-whttps://doaj.org/toc/2041-1723The molecular determinants of differential responses of different cancer cells to methionine restriction are poorly understood. Here the authors show that hepatocyte nuclear factor 4α regulates sulfur amino acid metabolism and dictates the sensitivity of liver cancer to this dietary manipulation.Qing XuYuanyuan LiXia GaoKai KangJason G. WilliamsLingfeng TongJuan LiuMing JiLeesa J. DeterdingXuemei TongJason W. LocasaleLeping LiIgor ShatsXiaoling LiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qing Xu Yuanyuan Li Xia Gao Kai Kang Jason G. Williams Lingfeng Tong Juan Liu Ming Ji Leesa J. Deterding Xuemei Tong Jason W. Locasale Leping Li Igor Shats Xiaoling Li HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
description	The molecular determinants of differential responses of different cancer cells to methionine restriction are poorly understood. Here the authors show that hepatocyte nuclear factor 4α regulates sulfur amino acid metabolism and dictates the sensitivity of liver cancer to this dietary manipulation.
format	article
author	Qing Xu Yuanyuan Li Xia Gao Kai Kang Jason G. Williams Lingfeng Tong Juan Liu Ming Ji Leesa J. Deterding Xuemei Tong Jason W. Locasale Leping Li Igor Shats Xiaoling Li
author_facet	Qing Xu Yuanyuan Li Xia Gao Kai Kang Jason G. Williams Lingfeng Tong Juan Liu Ming Ji Leesa J. Deterding Xuemei Tong Jason W. Locasale Leping Li Igor Shats Xiaoling Li
author_sort	Qing Xu
title	HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
title_short	HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
title_full	HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
title_fullStr	HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
title_full_unstemmed	HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
title_sort	hnf4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d7e9ce8d5e534383a649d3e167e248f8
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HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer

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