α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients

Management of end-stage renal disease (ESRD) patients requires monitoring each of the components of malnutrition–inflammation–atherosclerosis (MIA) syndrome. Restrictive diet can negatively affect nutritional status and inflammation. An acute-phase protein—α<sub>1</sub>-acid glycoprotein...

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Autores principales:	Małgorzata Maraj, Paulina Hetwer, Beata Kuśnierz-Cabala, Barbara Maziarz, Paulina Dumnicka, Marek Kuźniewski, Piotr Ceranowicz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hemodialysis end-stage kidney disease malnutrition dietary intake α<sub>1</sub>-acid glycoprotein appetite Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d7ea58797d5b4ef0a0920994210d4d51
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spelling	oai:doaj.org-article:d7ea58797d5b4ef0a0920994210d4d512021-11-25T18:33:00Zα<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients10.3390/nu131136712072-6643https://doaj.org/article/d7ea58797d5b4ef0a0920994210d4d512021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3671https://doaj.org/toc/2072-6643Management of end-stage renal disease (ESRD) patients requires monitoring each of the components of malnutrition–inflammation–atherosclerosis (MIA) syndrome. Restrictive diet can negatively affect nutritional status and inflammation. An acute-phase protein—α<sub>1</sub>-acid glycoprotein (AGP), has been associated with energy metabolism in animal and human studies. The aim of our study was to look for a relationship between serum AGP concentrations, laboratory parameters, and nutrient intake in ESRD patients. The study included 59 patients treated with maintenance hemodialysis. A 24 h recall assessed dietary intake during four non-consecutive days—two days in the post-summer period, and two post-winter. Selected laboratory tests were performed: complete blood count, serum iron, total iron biding capacity (TIBC) and unsaturated iron biding capacity (UIBC), vitamin D, AGP, C-reactive protein (CRP), albumin, prealbumin, and phosphate–calcium metabolism markers (intact parathyroid hormone, calcium, phosphate). Recorded dietary intake was highly deficient. A majority of patients did not meet recommended daily requirements for energy, protein, fiber, iron, magnesium, folate, and vitamin D. AGP correlated positively with CRP (R = 0.66), platelets (R = 0.29), and negatively with iron (R = −0.27) and TIBC (R = −0.30). AGP correlated negatively with the dietary intake of plant protein (R = −0.40), potassium (R = −0.27), copper (R = −0.30), vitamin B<sub>6</sub> (R = −0.27), and folates (R = −0.27), p < 0.05. However, in multiple regression adjusted for confounders, only CRP was significantly associated with AGP. Our results indicate that in hemodialyzed patients, serum AGP is weakly associated with dietary intake of several nutrients, including plant protein.Małgorzata MarajPaulina HetwerBeata Kuśnierz-CabalaBarbara MaziarzPaulina DumnickaMarek KuźniewskiPiotr CeranowiczMDPI AGarticlehemodialysisend-stage kidney diseasemalnutritiondietary intakeα<sub>1</sub>-acid glycoproteinappetiteNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3671, p 3671 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hemodialysis end-stage kidney disease malnutrition dietary intake α<sub>1</sub>-acid glycoprotein appetite Nutrition. Foods and food supply TX341-641
spellingShingle	hemodialysis end-stage kidney disease malnutrition dietary intake α<sub>1</sub>-acid glycoprotein appetite Nutrition. Foods and food supply TX341-641 Małgorzata Maraj Paulina Hetwer Beata Kuśnierz-Cabala Barbara Maziarz Paulina Dumnicka Marek Kuźniewski Piotr Ceranowicz α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients
description	Management of end-stage renal disease (ESRD) patients requires monitoring each of the components of malnutrition–inflammation–atherosclerosis (MIA) syndrome. Restrictive diet can negatively affect nutritional status and inflammation. An acute-phase protein—α<sub>1</sub>-acid glycoprotein (AGP), has been associated with energy metabolism in animal and human studies. The aim of our study was to look for a relationship between serum AGP concentrations, laboratory parameters, and nutrient intake in ESRD patients. The study included 59 patients treated with maintenance hemodialysis. A 24 h recall assessed dietary intake during four non-consecutive days—two days in the post-summer period, and two post-winter. Selected laboratory tests were performed: complete blood count, serum iron, total iron biding capacity (TIBC) and unsaturated iron biding capacity (UIBC), vitamin D, AGP, C-reactive protein (CRP), albumin, prealbumin, and phosphate–calcium metabolism markers (intact parathyroid hormone, calcium, phosphate). Recorded dietary intake was highly deficient. A majority of patients did not meet recommended daily requirements for energy, protein, fiber, iron, magnesium, folate, and vitamin D. AGP correlated positively with CRP (R = 0.66), platelets (R = 0.29), and negatively with iron (R = −0.27) and TIBC (R = −0.30). AGP correlated negatively with the dietary intake of plant protein (R = −0.40), potassium (R = −0.27), copper (R = −0.30), vitamin B<sub>6</sub> (R = −0.27), and folates (R = −0.27), p < 0.05. However, in multiple regression adjusted for confounders, only CRP was significantly associated with AGP. Our results indicate that in hemodialyzed patients, serum AGP is weakly associated with dietary intake of several nutrients, including plant protein.
format	article
author	Małgorzata Maraj Paulina Hetwer Beata Kuśnierz-Cabala Barbara Maziarz Paulina Dumnicka Marek Kuźniewski Piotr Ceranowicz
author_facet	Małgorzata Maraj Paulina Hetwer Beata Kuśnierz-Cabala Barbara Maziarz Paulina Dumnicka Marek Kuźniewski Piotr Ceranowicz
author_sort	Małgorzata Maraj
title	α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients
title_short	α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients
title_full	α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients
title_fullStr	α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients
title_full_unstemmed	α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients
title_sort	α<sub>1</sub>-acid glycoprotein and dietary intake in end-stage renal disease patients
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d7ea58797d5b4ef0a0920994210d4d51
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α<sub>1</sub>-Acid Glycoprotein and Dietary Intake in End-Stage Renal Disease Patients

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