Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease

Here the authors present an approach that can reveal the full complement of mRNA isoforms encoded by individual genes, and they identify a major isoform of the retinal degeneration gene CRB1 which functions at the cell-cell junctions of the outer limiting membrane to promote photoreceptor survival.

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Autores principales:	Thomas A. Ray, Kelly Cochran, Chris Kozlowski, Jingjing Wang, Graham Alexander, Martha A. Cady, William J. Spencer, Philip A. Ruzycki, Brian S. Clark, Annelies Laeremans, Ming-Xiao He, Xiaoming Wang, Emily Park, Ying Hao, Alessandro Iannaccone, Gary Hu, Olivier Fedrigo, Nikolai P. Skiba, Vadim Y. Arshavsky, Jeremy N. Kay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7eafb0bbaa4448cab111eaa3196f3ce
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spelling	oai:doaj.org-article:d7eafb0bbaa4448cab111eaa3196f3ce2021-12-02T16:32:14ZComprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease10.1038/s41467-020-17009-72041-1723https://doaj.org/article/d7eafb0bbaa4448cab111eaa3196f3ce2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17009-7https://doaj.org/toc/2041-1723Here the authors present an approach that can reveal the full complement of mRNA isoforms encoded by individual genes, and they identify a major isoform of the retinal degeneration gene CRB1 which functions at the cell-cell junctions of the outer limiting membrane to promote photoreceptor survival.Thomas A. RayKelly CochranChris KozlowskiJingjing WangGraham AlexanderMartha A. CadyWilliam J. SpencerPhilip A. RuzyckiBrian S. ClarkAnnelies LaeremansMing-Xiao HeXiaoming WangEmily ParkYing HaoAlessandro IannacconeGary HuOlivier FedrigoNikolai P. SkibaVadim Y. ArshavskyJeremy N. KayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas A. Ray Kelly Cochran Chris Kozlowski Jingjing Wang Graham Alexander Martha A. Cady William J. Spencer Philip A. Ruzycki Brian S. Clark Annelies Laeremans Ming-Xiao He Xiaoming Wang Emily Park Ying Hao Alessandro Iannaccone Gary Hu Olivier Fedrigo Nikolai P. Skiba Vadim Y. Arshavsky Jeremy N. Kay Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
description	Here the authors present an approach that can reveal the full complement of mRNA isoforms encoded by individual genes, and they identify a major isoform of the retinal degeneration gene CRB1 which functions at the cell-cell junctions of the outer limiting membrane to promote photoreceptor survival.
format	article
author	Thomas A. Ray Kelly Cochran Chris Kozlowski Jingjing Wang Graham Alexander Martha A. Cady William J. Spencer Philip A. Ruzycki Brian S. Clark Annelies Laeremans Ming-Xiao He Xiaoming Wang Emily Park Ying Hao Alessandro Iannaccone Gary Hu Olivier Fedrigo Nikolai P. Skiba Vadim Y. Arshavsky Jeremy N. Kay
author_facet	Thomas A. Ray Kelly Cochran Chris Kozlowski Jingjing Wang Graham Alexander Martha A. Cady William J. Spencer Philip A. Ruzycki Brian S. Clark Annelies Laeremans Ming-Xiao He Xiaoming Wang Emily Park Ying Hao Alessandro Iannaccone Gary Hu Olivier Fedrigo Nikolai P. Skiba Vadim Y. Arshavsky Jeremy N. Kay
author_sort	Thomas A. Ray
title	Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
title_short	Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
title_full	Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
title_fullStr	Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
title_full_unstemmed	Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
title_sort	comprehensive identification of mrna isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d7eafb0bbaa4448cab111eaa3196f3ce
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Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease

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