Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells

Topologically associating domain (TAD) boundaries in flies seem to be different from those in mammals. Here, the authors use Hi-C with sub-kb resolution to identify about 4000 TADs in flies, most demarcated by the insulator complexes BEAF-32/CP190 or BEAF-32/Chromator like CTCF/cohesin in mammals.

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Autores principales:	Qi Wang, Qiu Sun, Daniel M. Czajkowsky, Zhifeng Shao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d7ec9baf4799424fa4f9a7f981da068b
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spelling	oai:doaj.org-article:d7ec9baf4799424fa4f9a7f981da068b2021-12-02T16:56:43ZSub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells10.1038/s41467-017-02526-92041-1723https://doaj.org/article/d7ec9baf4799424fa4f9a7f981da068b2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02526-9https://doaj.org/toc/2041-1723Topologically associating domain (TAD) boundaries in flies seem to be different from those in mammals. Here, the authors use Hi-C with sub-kb resolution to identify about 4000 TADs in flies, most demarcated by the insulator complexes BEAF-32/CP190 or BEAF-32/Chromator like CTCF/cohesin in mammals.Qi WangQiu SunDaniel M. CzajkowskyZhifeng ShaoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qi Wang Qiu Sun Daniel M. Czajkowsky Zhifeng Shao Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
description	Topologically associating domain (TAD) boundaries in flies seem to be different from those in mammals. Here, the authors use Hi-C with sub-kb resolution to identify about 4000 TADs in flies, most demarcated by the insulator complexes BEAF-32/CP190 or BEAF-32/Chromator like CTCF/cohesin in mammals.
format	article
author	Qi Wang Qiu Sun Daniel M. Czajkowsky Zhifeng Shao
author_facet	Qi Wang Qiu Sun Daniel M. Czajkowsky Zhifeng Shao
author_sort	Qi Wang
title	Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
title_short	Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
title_full	Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
title_fullStr	Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
title_full_unstemmed	Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells
title_sort	sub-kb hi-c in d. melanogaster reveals conserved characteristics of tads between insect and mammalian cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d7ec9baf4799424fa4f9a7f981da068b
work_keys_str_mv	AT qiwang subkbhicindmelanogasterrevealsconservedcharacteristicsoftadsbetweeninsectandmammaliancells AT qiusun subkbhicindmelanogasterrevealsconservedcharacteristicsoftadsbetweeninsectandmammaliancells AT danielmczajkowsky subkbhicindmelanogasterrevealsconservedcharacteristicsoftadsbetweeninsectandmammaliancells AT zhifengshao subkbhicindmelanogasterrevealsconservedcharacteristicsoftadsbetweeninsectandmammaliancells
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Sub-kb Hi-C in D. melanogaster reveals conserved characteristics of TADs between insect and mammalian cells

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