Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway

Objectives: The adverse deleterious influences of Ipomoea carnea on brain tissue and Taurine's relative ability to prevent this neurotoxicity have been examined. Methods: We utilized sixty Wistar male rats weighing 1752 g. The rats were allotted into 4 groups of fifteen each: The control group...

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Autores principales:	Asmaa R. Abou El-khair, Nora Ghanem, Samaa bakr, Mohamed Mohamed Soliman, Adil Aldhahrani, Mayada R. Farag, Mohamed E. Abd El-Hack, Mustafa Shukry
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Taurine Ipomoea carnea Oxidative injury Apoptosis Nuclear factor (erythroid-derived 2)-like 2 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/d7f066a63ac94c169143c6b87c3945d7
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spelling	oai:doaj.org-article:d7f066a63ac94c169143c6b87c3945d72021-11-18T04:44:16ZAmeliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway1018-364710.1016/j.jksus.2021.101639https://doaj.org/article/d7f066a63ac94c169143c6b87c3945d72021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1018364721003013https://doaj.org/toc/1018-3647Objectives: The adverse deleterious influences of Ipomoea carnea on brain tissue and Taurine's relative ability to prevent this neurotoxicity have been examined. Methods: We utilized sixty Wistar male rats weighing 1752 g. The rats were allotted into 4 groups of fifteen each: The control group got saline i.p. daily for eight weeks; the Ipomoea carnea extract (ICE) group received ICE (15 mg/kg b.w./day) orally for eight weeks. Taurine-treated rats, in which rats were administered Taurine (200 mg·kg−1, i.p./Day) for 2 months. Taurine + ICE group in which rats were supplemented with (200 mg·kg−1, i.p. Taurine + ICE 15 mg/kg b.w./day orally) for 2 months. Result: The findings indicated that Ipomoea persuaded an increase in lipid peroxidation markers as well as a disruption in antioxidant homeostasis, along with brain and serum cholinesterase (AChE) elevated levels, tumor necrosis factor (TNF), total creatine phosphokinase (CPK), creatine phosphokinase isoenzymes BB (CPK-BB), and lactate dehydrogenase (LDH). A considerable drop (P < 0.05) in the brain superoxide dismutase (SOD), catalase (CAT), and GSH in Ipomoea carnea. SOD, CAT, and GSH levels were enhanced in the Taurine co-treated group but did not achieve control levels. Ipomoea Furthermore, Induced apoptosis in brain tissue by Ipomoea carnea reflected in pro-apoptotic Bax, P53, and caspase 3 overexpression., while taurine upregulated the anti-apoptotic Bcl2 in addition to Histopathologic, electron microscope, and immunohistological brain examination finding support our finding concerning the protective role of taurine. Conclusion: Our study proved the protective role of taurine as a supplement could recover Ipomoea carnea -induced oxidative changes and brain damage.Asmaa R. Abou El-khairNora GhanemSamaa bakrMohamed Mohamed SolimanAdil AldhahraniMayada R. FaragMohamed E. Abd El-HackMustafa ShukryElsevierarticleTaurineIpomoea carneaOxidative injuryApoptosisNuclear factor (erythroid-derived 2)-like 2Science (General)Q1-390ENJournal of King Saud University: Science, Vol 33, Iss 8, Pp 101639- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Taurine Ipomoea carnea Oxidative injury Apoptosis Nuclear factor (erythroid-derived 2)-like 2 Science (General) Q1-390
spellingShingle	Taurine Ipomoea carnea Oxidative injury Apoptosis Nuclear factor (erythroid-derived 2)-like 2 Science (General) Q1-390 Asmaa R. Abou El-khair Nora Ghanem Samaa bakr Mohamed Mohamed Soliman Adil Aldhahrani Mayada R. Farag Mohamed E. Abd El-Hack Mustafa Shukry Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway
description	Objectives: The adverse deleterious influences of Ipomoea carnea on brain tissue and Taurine's relative ability to prevent this neurotoxicity have been examined. Methods: We utilized sixty Wistar male rats weighing 1752 g. The rats were allotted into 4 groups of fifteen each: The control group got saline i.p. daily for eight weeks; the Ipomoea carnea extract (ICE) group received ICE (15 mg/kg b.w./day) orally for eight weeks. Taurine-treated rats, in which rats were administered Taurine (200 mg·kg−1, i.p./Day) for 2 months. Taurine + ICE group in which rats were supplemented with (200 mg·kg−1, i.p. Taurine + ICE 15 mg/kg b.w./day orally) for 2 months. Result: The findings indicated that Ipomoea persuaded an increase in lipid peroxidation markers as well as a disruption in antioxidant homeostasis, along with brain and serum cholinesterase (AChE) elevated levels, tumor necrosis factor (TNF), total creatine phosphokinase (CPK), creatine phosphokinase isoenzymes BB (CPK-BB), and lactate dehydrogenase (LDH). A considerable drop (P < 0.05) in the brain superoxide dismutase (SOD), catalase (CAT), and GSH in Ipomoea carnea. SOD, CAT, and GSH levels were enhanced in the Taurine co-treated group but did not achieve control levels. Ipomoea Furthermore, Induced apoptosis in brain tissue by Ipomoea carnea reflected in pro-apoptotic Bax, P53, and caspase 3 overexpression., while taurine upregulated the anti-apoptotic Bcl2 in addition to Histopathologic, electron microscope, and immunohistological brain examination finding support our finding concerning the protective role of taurine. Conclusion: Our study proved the protective role of taurine as a supplement could recover Ipomoea carnea -induced oxidative changes and brain damage.
format	article
author	Asmaa R. Abou El-khair Nora Ghanem Samaa bakr Mohamed Mohamed Soliman Adil Aldhahrani Mayada R. Farag Mohamed E. Abd El-Hack Mustafa Shukry
author_facet	Asmaa R. Abou El-khair Nora Ghanem Samaa bakr Mohamed Mohamed Soliman Adil Aldhahrani Mayada R. Farag Mohamed E. Abd El-Hack Mustafa Shukry
author_sort	Asmaa R. Abou El-khair
title	Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway
title_short	Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway
title_full	Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway
title_fullStr	Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway
title_full_unstemmed	Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway
title_sort	ameliorative impact of taurine on oxidative damage induced by ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and nrf2 pathway
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d7f066a63ac94c169143c6b87c3945d7
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Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway

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