The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy

Congenital obstructive nephropathy (CON) leads to renal fibrosis and chronic kidney disease. The aim of the study was to investigate the predictive value of urinary endoglin, periostin, cytokeratin-18, and transforming growth factor-β1 (TGF-β1) for assessing the severity of renal fibrosis in 81 chil...

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Autores principales:	Agnieszka Turczyn, Małgorzata Pańczyk-Tomaszewska, Grażyna Krzemień, Elżbieta Górska, Urszula Demkow
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	periostin cytokeratin-18 endoglin transforming growth factor-β1 renal fibrosis congenital obstructive nephropathy Medicine R
Acceso en línea:	https://doaj.org/article/d7f3872eacb14e5587a67167437c347d
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spelling	oai:doaj.org-article:d7f3872eacb14e5587a67167437c347d2021-11-11T17:32:55ZThe Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy10.3390/jcm102148992077-0383https://doaj.org/article/d7f3872eacb14e5587a67167437c347d2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4899https://doaj.org/toc/2077-0383Congenital obstructive nephropathy (CON) leads to renal fibrosis and chronic kidney disease. The aim of the study was to investigate the predictive value of urinary endoglin, periostin, cytokeratin-18, and transforming growth factor-β1 (TGF-β1) for assessing the severity of renal fibrosis in 81 children with CON and 60 controls. Children were divided into three subgroups: severe, moderate scars, and borderline lesions based on 99mTc-ethylenedicysteine scintigraphy results. Periostin, periostin/Cr, and cytokeratin-18 levels were significantly higher in the study group compared to the controls. Children with severe scars had significantly higher urinary periostin/Cr levels than those with borderline lesions. In multivariate analysis, only periostin and cytokeratin-18 were independently related to the presence of severe and moderate scars, and periostin was independently related to borderline lesions. However, periostin did not differentiate advanced scars from borderline lesions. In ROC analysis, periostin and periostin/Cr demonstrated better diagnostic profiles for detection of advanced scars than TGF-β1 and cytokeratin-18 (AUC 0.849; 0.810 vs. 0.630; 0.611, respectively) and periostin for detecting borderline lesions than endoglin and periostin/Cr (AUC 0.777 vs. 0.661; 0.658, respectively). In conclusion, periostin seems to be a promising, non-invasive marker for assessing renal fibrosis in children with CON. CK-18 and TGF-β1 demonstrated low utility, and endoglin was not useful for diagnosing advanced scars.Agnieszka TurczynMałgorzata Pańczyk-TomaszewskaGrażyna KrzemieńElżbieta GórskaUrszula DemkowMDPI AGarticleperiostincytokeratin-18endoglintransforming growth factor-β1renal fibrosiscongenital obstructive nephropathyMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4899, p 4899 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	periostin cytokeratin-18 endoglin transforming growth factor-β1 renal fibrosis congenital obstructive nephropathy Medicine R
spellingShingle	periostin cytokeratin-18 endoglin transforming growth factor-β1 renal fibrosis congenital obstructive nephropathy Medicine R Agnieszka Turczyn Małgorzata Pańczyk-Tomaszewska Grażyna Krzemień Elżbieta Górska Urszula Demkow The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy
description	Congenital obstructive nephropathy (CON) leads to renal fibrosis and chronic kidney disease. The aim of the study was to investigate the predictive value of urinary endoglin, periostin, cytokeratin-18, and transforming growth factor-β1 (TGF-β1) for assessing the severity of renal fibrosis in 81 children with CON and 60 controls. Children were divided into three subgroups: severe, moderate scars, and borderline lesions based on 99mTc-ethylenedicysteine scintigraphy results. Periostin, periostin/Cr, and cytokeratin-18 levels were significantly higher in the study group compared to the controls. Children with severe scars had significantly higher urinary periostin/Cr levels than those with borderline lesions. In multivariate analysis, only periostin and cytokeratin-18 were independently related to the presence of severe and moderate scars, and periostin was independently related to borderline lesions. However, periostin did not differentiate advanced scars from borderline lesions. In ROC analysis, periostin and periostin/Cr demonstrated better diagnostic profiles for detection of advanced scars than TGF-β1 and cytokeratin-18 (AUC 0.849; 0.810 vs. 0.630; 0.611, respectively) and periostin for detecting borderline lesions than endoglin and periostin/Cr (AUC 0.777 vs. 0.661; 0.658, respectively). In conclusion, periostin seems to be a promising, non-invasive marker for assessing renal fibrosis in children with CON. CK-18 and TGF-β1 demonstrated low utility, and endoglin was not useful for diagnosing advanced scars.
format	article
author	Agnieszka Turczyn Małgorzata Pańczyk-Tomaszewska Grażyna Krzemień Elżbieta Górska Urszula Demkow
author_facet	Agnieszka Turczyn Małgorzata Pańczyk-Tomaszewska Grażyna Krzemień Elżbieta Górska Urszula Demkow
author_sort	Agnieszka Turczyn
title	The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy
title_short	The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy
title_full	The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy
title_fullStr	The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy
title_full_unstemmed	The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy
title_sort	usefulness of urinary periostin, cytokeratin-18, and endoglin for diagnosing renal fibrosis in children with congenital obstructive nephropathy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d7f3872eacb14e5587a67167437c347d
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The Usefulness of Urinary Periostin, Cytokeratin-18, and Endoglin for Diagnosing Renal Fibrosis in Children with Congenital Obstructive Nephropathy

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