Apparent diffusion coefficient as a prognostic factor in clival chordoma

Abstract Clival chordoma is a rare disease with high recurrence rates even after a combination of surgical resection and radiotherapy. Apparent diffusion coefficient (ADC) has been used to evaluate aggressive features of chordoma, but its utility for clival chordoma has not been explored specificall...

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Autores principales:	Hyeong-Cheol Oh, Chang-Ki Hong, Kyu-Sung Lee, Yoon Jin Cha, Sung Jun Ahn, Sang Hyun Suh, Hun Ho Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7f40c3bfb3e4293a480bbc0cd624984
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spelling	oai:doaj.org-article:d7f40c3bfb3e4293a480bbc0cd6249842021-12-02T15:23:06ZApparent diffusion coefficient as a prognostic factor in clival chordoma10.1038/s41598-020-79894-82045-2322https://doaj.org/article/d7f40c3bfb3e4293a480bbc0cd6249842021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79894-8https://doaj.org/toc/2045-2322Abstract Clival chordoma is a rare disease with high recurrence rates even after a combination of surgical resection and radiotherapy. Apparent diffusion coefficient (ADC) has been used to evaluate aggressive features of chordoma, but its utility for clival chordoma has not been explored specifically. In this study, the utility of preoperative ADC values was analyzed for predicting tumor progression and recurrence in patients with clival chordoma. Between 2012 and 2019, a total of 30 operated cases were analyzed with available preoperative ADC data. Receiver operating characteristic (ROC) analysis was used to obtain ADC cutoff values for predicting tumor aggressiveness. The mean and minimum ADC values were significantly lower in the aggressive tumor group than in the stable tumor group (both P < 0.001). ROC analysis showed that a mean cutoff ADC value of 1198 × 10−6 mm2/s and minimum ADC value of 895.5 × 10–6 mm2/s could be used to predict aggressive features of clival chordoma. Subtotal resection, partial resection, and mean and minimum ADC values that were lower than cutoff values were negative predictors of overall survival and progression-free survival. In conclusion, mean and minimum ADC values could be useful in predicting aggressiveness of clival chordoma.Hyeong-Cheol OhChang-Ki HongKyu-Sung LeeYoon Jin ChaSung Jun AhnSang Hyun SuhHun Ho ParkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hyeong-Cheol Oh Chang-Ki Hong Kyu-Sung Lee Yoon Jin Cha Sung Jun Ahn Sang Hyun Suh Hun Ho Park Apparent diffusion coefficient as a prognostic factor in clival chordoma
description	Abstract Clival chordoma is a rare disease with high recurrence rates even after a combination of surgical resection and radiotherapy. Apparent diffusion coefficient (ADC) has been used to evaluate aggressive features of chordoma, but its utility for clival chordoma has not been explored specifically. In this study, the utility of preoperative ADC values was analyzed for predicting tumor progression and recurrence in patients with clival chordoma. Between 2012 and 2019, a total of 30 operated cases were analyzed with available preoperative ADC data. Receiver operating characteristic (ROC) analysis was used to obtain ADC cutoff values for predicting tumor aggressiveness. The mean and minimum ADC values were significantly lower in the aggressive tumor group than in the stable tumor group (both P < 0.001). ROC analysis showed that a mean cutoff ADC value of 1198 × 10−6 mm2/s and minimum ADC value of 895.5 × 10–6 mm2/s could be used to predict aggressive features of clival chordoma. Subtotal resection, partial resection, and mean and minimum ADC values that were lower than cutoff values were negative predictors of overall survival and progression-free survival. In conclusion, mean and minimum ADC values could be useful in predicting aggressiveness of clival chordoma.
format	article
author	Hyeong-Cheol Oh Chang-Ki Hong Kyu-Sung Lee Yoon Jin Cha Sung Jun Ahn Sang Hyun Suh Hun Ho Park
author_facet	Hyeong-Cheol Oh Chang-Ki Hong Kyu-Sung Lee Yoon Jin Cha Sung Jun Ahn Sang Hyun Suh Hun Ho Park
author_sort	Hyeong-Cheol Oh
title	Apparent diffusion coefficient as a prognostic factor in clival chordoma
title_short	Apparent diffusion coefficient as a prognostic factor in clival chordoma
title_full	Apparent diffusion coefficient as a prognostic factor in clival chordoma
title_fullStr	Apparent diffusion coefficient as a prognostic factor in clival chordoma
title_full_unstemmed	Apparent diffusion coefficient as a prognostic factor in clival chordoma
title_sort	apparent diffusion coefficient as a prognostic factor in clival chordoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d7f40c3bfb3e4293a480bbc0cd624984
work_keys_str_mv	AT hyeongcheoloh apparentdiffusioncoefficientasaprognosticfactorinclivalchordoma AT changkihong apparentdiffusioncoefficientasaprognosticfactorinclivalchordoma AT kyusunglee apparentdiffusioncoefficientasaprognosticfactorinclivalchordoma AT yoonjincha apparentdiffusioncoefficientasaprognosticfactorinclivalchordoma AT sungjunahn apparentdiffusioncoefficientasaprognosticfactorinclivalchordoma AT sanghyunsuh apparentdiffusioncoefficientasaprognosticfactorinclivalchordoma AT hunhopark apparentdiffusioncoefficientasaprognosticfactorinclivalchordoma
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Apparent diffusion coefficient as a prognostic factor in clival chordoma

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