Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease
Hatice Kose Ozlece,1 Gulname Findik Guvendi,2 Nergiz Huseyinoglu,1 Yusuf Ehi,3 Yuksel Kivrak4 1Department of Neurology, Acibadem Kayseri Hospital, Kayseri, Turkey; 2Department of Pathology, Medical Faculty, Kafkas University, Kars, Turkey; 3Department of Neurology, Medical Faculty, Kafkas Universit...
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Dove Medical Press
2018
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oai:doaj.org-article:d7f40c5c502e4773aac23b2d39fc93e22021-12-02T04:18:10ZCytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease1178-2021https://doaj.org/article/d7f40c5c502e4773aac23b2d39fc93e22018-07-01T00:00:00Zhttps://www.dovepress.com/cytological-and-cytometric-analysis-of-oral-mucosa-in-patients-with-al-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hatice Kose Ozlece,1 Gulname Findik Guvendi,2 Nergiz Huseyinoglu,1 Yusuf Ehi,3 Yuksel Kivrak4 1Department of Neurology, Acibadem Kayseri Hospital, Kayseri, Turkey; 2Department of Pathology, Medical Faculty, Kafkas University, Kars, Turkey; 3Department of Neurology, Medical Faculty, Kafkas University, Kars, Turkey; 4Department of Psychiatry, Medical Faculty, Kafkas University, Kars, Turkey Background: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative diseases. Recent studies have sought to identify precursor symptoms of AD and PD that occur before the onset of the disease. We evaluated changes in the oral mucosa of patients with AD and PD using a stereological method. Patients and methods: The study included 29 patients with AD, 30 patients with idiopathic PD, and 30 healthy volunteers. Brush biopsies were obtained from all participants, and the nucleator method was used to estimate the volume of cells obtained from the buccal mucosa. Results: Cytomorphometric analysis revealed that the nuclear volume was 484.39±117.10 µm3 in the AD group, 509.71±132.26 µm3 in PD patients, and 509.30±100.21 µm3 in the control group. The cytoplasmic volume was 115,456.60±30,664.98 µm3 in the AD group, 103,097.93±25,034.65 µm3 in PD patients, and 109,528.45±28,381.43 µm3 in the control group. The nuclear and cytoplasmic volumes were not significantly different among groups (P>0.05). Conclusion: The cytomorphometric analysis revealed no significant differences in the cytoplasmic and nuclear volumes of buccal cells obtained from patients with AD and PD and healthy volunteers. Keywords: Alzheimer’s disease, Parkinson’s disease, exfoliative cytology, stereology, oral mucosaKose Ozlece HFindik Guvendi GHuseyinoglu NEhi YKivrak YDove Medical PressarticleAlzheimer’s DiseaseParkinson’s Diseaseexfoliative cytologystereologyoral mucosaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 1901-1906 (2018) |
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| collection |
DOAJ |
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Alzheimer’s Disease Parkinson’s Disease exfoliative cytology stereology oral mucosa Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
| spellingShingle |
Alzheimer’s Disease Parkinson’s Disease exfoliative cytology stereology oral mucosa Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kose Ozlece H Findik Guvendi G Huseyinoglu N Ehi Y Kivrak Y Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease |
| description |
Hatice Kose Ozlece,1 Gulname Findik Guvendi,2 Nergiz Huseyinoglu,1 Yusuf Ehi,3 Yuksel Kivrak4 1Department of Neurology, Acibadem Kayseri Hospital, Kayseri, Turkey; 2Department of Pathology, Medical Faculty, Kafkas University, Kars, Turkey; 3Department of Neurology, Medical Faculty, Kafkas University, Kars, Turkey; 4Department of Psychiatry, Medical Faculty, Kafkas University, Kars, Turkey Background: Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the two most common neurodegenerative diseases. Recent studies have sought to identify precursor symptoms of AD and PD that occur before the onset of the disease. We evaluated changes in the oral mucosa of patients with AD and PD using a stereological method. Patients and methods: The study included 29 patients with AD, 30 patients with idiopathic PD, and 30 healthy volunteers. Brush biopsies were obtained from all participants, and the nucleator method was used to estimate the volume of cells obtained from the buccal mucosa. Results: Cytomorphometric analysis revealed that the nuclear volume was 484.39±117.10 µm3 in the AD group, 509.71±132.26 µm3 in PD patients, and 509.30±100.21 µm3 in the control group. The cytoplasmic volume was 115,456.60±30,664.98 µm3 in the AD group, 103,097.93±25,034.65 µm3 in PD patients, and 109,528.45±28,381.43 µm3 in the control group. The nuclear and cytoplasmic volumes were not significantly different among groups (P>0.05). Conclusion: The cytomorphometric analysis revealed no significant differences in the cytoplasmic and nuclear volumes of buccal cells obtained from patients with AD and PD and healthy volunteers. Keywords: Alzheimer’s disease, Parkinson’s disease, exfoliative cytology, stereology, oral mucosa |
| format |
article |
| author |
Kose Ozlece H Findik Guvendi G Huseyinoglu N Ehi Y Kivrak Y |
| author_facet |
Kose Ozlece H Findik Guvendi G Huseyinoglu N Ehi Y Kivrak Y |
| author_sort |
Kose Ozlece H |
| title |
Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease |
| title_short |
Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease |
| title_full |
Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease |
| title_fullStr |
Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease |
| title_full_unstemmed |
Cytological and cytometric analysis of oral mucosa in patients with Alzheimer’s and Parkinson’s disease |
| title_sort |
cytological and cytometric analysis of oral mucosa in patients with alzheimer’s and parkinson’s disease |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/d7f40c5c502e4773aac23b2d39fc93e2 |
| work_keys_str_mv |
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| _version_ |
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