Attenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 function.

Attenuation of soft-tissue sarcomas resistance to the cytotoxic action of TNF-α by restoring p53 function.

<h4>Background</h4>Isolated limb perfusion with TNF-α and melphalan is used with remarkable efficiency to treat unresectable limb sarcomas. Here we tested the ability of TNF-α to directly induce apoptosis of sarcoma cells. In addition, we investigated the impact of p53 in the regulation...

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Autores principales: Jane Muret, Meriem Hasmim, Izabela Stasik, Abdelali Jalil, Aude Mallavialle, Arash Nanbakhsh, Ludovic Lacroix, Katy Billot, Véronique Baud, Jérome Thiery, Philippe Vielh, Philippe Terrier, Joelle Wiels, Lyubomir Vassilev, Axel Lecesne, Sylvie Bonvalot, Salem Chouaib
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d7f4a17893274733b648d7cb83c3aa30
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