Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease

Abstract Our perception of the world is remarkably stable despite of distorted retinal input due to frequent eye movements. It is considered that the brain uses corollary discharge, efference copies of signals sent from motor to visual regions, to compensate for distortions and stabilize visual perc...

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Autores principales:	Jingru Wang, Xiaojun Guo, Xianbo Zhuang, Tuanzhi Chen, Wei Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7f5df375b184502b30c492c4072fa46
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spelling	oai:doaj.org-article:d7f5df375b184502b30c492c4072fa462021-12-02T11:52:38ZDisrupted pursuit compensation during self-motion perception in early Alzheimer’s disease10.1038/s41598-017-04377-22045-2322https://doaj.org/article/d7f5df375b184502b30c492c4072fa462017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04377-2https://doaj.org/toc/2045-2322Abstract Our perception of the world is remarkably stable despite of distorted retinal input due to frequent eye movements. It is considered that the brain uses corollary discharge, efference copies of signals sent from motor to visual regions, to compensate for distortions and stabilize visual perception. In this study, we tested whether patients with Alzheimer’s disease (AD) have impaired corollary discharge functions as evidenced by reduced compensation during the perception of optic flow that mimics self-motion in the environment. We asked a group of early-stage AD patients and age-matched healthy controls to indicate the perceived direction of self-motion based on optic flow while tracking a moving target with smooth pursuit eye movement, or keeping eye fixation at a stationary target. We first replicated the previous findings that healthy participants were able to compensate for distorted optic flow in the presence of eye movements, as indicated by similar performance of self-motion perception between pursuit and fixation conditions. In stark contrast, AD patients showed impaired self-motion perception when the optic flow was distorted by eye movements. Our results suggest that early-stage AD pathology is associated with disrupted eye movement compensation during self-motion perception.Jingru WangXiaojun GuoXianbo ZhuangTuanzhi ChenWei YanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jingru Wang Xiaojun Guo Xianbo Zhuang Tuanzhi Chen Wei Yan Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease
description	Abstract Our perception of the world is remarkably stable despite of distorted retinal input due to frequent eye movements. It is considered that the brain uses corollary discharge, efference copies of signals sent from motor to visual regions, to compensate for distortions and stabilize visual perception. In this study, we tested whether patients with Alzheimer’s disease (AD) have impaired corollary discharge functions as evidenced by reduced compensation during the perception of optic flow that mimics self-motion in the environment. We asked a group of early-stage AD patients and age-matched healthy controls to indicate the perceived direction of self-motion based on optic flow while tracking a moving target with smooth pursuit eye movement, or keeping eye fixation at a stationary target. We first replicated the previous findings that healthy participants were able to compensate for distorted optic flow in the presence of eye movements, as indicated by similar performance of self-motion perception between pursuit and fixation conditions. In stark contrast, AD patients showed impaired self-motion perception when the optic flow was distorted by eye movements. Our results suggest that early-stage AD pathology is associated with disrupted eye movement compensation during self-motion perception.
format	article
author	Jingru Wang Xiaojun Guo Xianbo Zhuang Tuanzhi Chen Wei Yan
author_facet	Jingru Wang Xiaojun Guo Xianbo Zhuang Tuanzhi Chen Wei Yan
author_sort	Jingru Wang
title	Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease
title_short	Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease
title_full	Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease
title_fullStr	Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease
title_full_unstemmed	Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease
title_sort	disrupted pursuit compensation during self-motion perception in early alzheimer’s disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d7f5df375b184502b30c492c4072fa46
work_keys_str_mv	AT jingruwang disruptedpursuitcompensationduringselfmotionperceptioninearlyalzheimersdisease AT xiaojunguo disruptedpursuitcompensationduringselfmotionperceptioninearlyalzheimersdisease AT xianbozhuang disruptedpursuitcompensationduringselfmotionperceptioninearlyalzheimersdisease AT tuanzhichen disruptedpursuitcompensationduringselfmotionperceptioninearlyalzheimersdisease AT weiyan disruptedpursuitcompensationduringselfmotionperceptioninearlyalzheimersdisease
_version_	1718395013923078144

Disrupted pursuit compensation during self-motion perception in early Alzheimer’s disease

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