Cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder

Jana Vyskocilova,1 Jan Prasko,2 Jiri Sipek3 1Faculty of Humanities, Charles University in Prague, Prague, 2Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, 3Department of Psychology, Faculty of Arts, Charles University in...

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Autores principales: Vyskocilova J, Prasko J, Sipek J
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Publicado: Dove Medical Press 2016
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spelling oai:doaj.org-article:d7f6c9661ea045999d8ff94c0c85161c2021-12-02T02:33:47ZCognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder1178-2021https://doaj.org/article/d7f6c9661ea045999d8ff94c0c85161c2016-03-01T00:00:00Zhttps://www.dovepress.com/cognitive-behavioral-therapy-in-pharmacoresistant-obsessivendashcompul-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jana Vyskocilova,1 Jan Prasko,2 Jiri Sipek3 1Faculty of Humanities, Charles University in Prague, Prague, 2Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, 3Department of Psychology, Faculty of Arts, Charles University in Prague, Prague, Czech Republic Background: The aim of the study was to determine whether patients with obsessive–compulsive disorder (OCD) resistant to drug therapy may improve their condition using intensive, systematic cognitive behavioral therapy (CBT) lasting for 6 weeks, and whether it is possible to predict the therapeutic effect using demographic, clinical, and selected psychological characteristics at baseline. Methods: Sixty-six OCD patients were included in the study, of which 57 completed the program. The diagnosis was confirmed using the structured Mini International Neuropsychiatric Interview. Patients were rated using the objective and subjective forms of the Yale–Brown Obsessive Compulsive Scale, objective and subjective forms of the Clinical Global Impression, Beck Anxiety Inventory, Beck Depression Inventory, Dissociative Experiences Scale, 20-item Somatoform Dissociation Questionnaire, and the Sheehan Disability Scale before their treatment, and with subjective Yale–Brown Obsessive Compulsive Scale, objective and subjective Clinical Global Impression, Beck Anxiety Inventory, and Beck Depression Inventory at the end of the treatment. Patients were treated with antidepressants and daily intensive group CBT for the 6-week period. Results: During the 6-week intensive CBT program in combination with pharmacotherapy, there was a significant improvement in patients suffering from OCD resistant to drug treatment. There were statistically significantly decrease in the scores assessing the severity of OCD symptoms, anxiety, and depressive feelings. A lower treatment effect was achieved specifically in patients who 1) showed fewer OCD themes in symptomatology, 2) showed a higher level of somatoform dissociation, 3) had poor insight, and 4) had a higher initial level of overall severity of the disorder. Remission of the disorder was more likely in patients who had 1) good insight, 2) a lower initial level of anxiety, and 3) no comorbid depressive disorder. Keywords: obsessive–compulsive disorder, treatment, cognitive behavioral therapy, treatment resistance, treatment efficacy, predictorsVyskocilova JPrasko JSipek JDove Medical PressarticleObsessive-compulsive disorder / treatment / cognitive behavioral therapy / treatment resistance / treatment efficacy / predictors.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 625-639 (2016)
institution DOAJ
collection DOAJ
language EN
topic Obsessive-compulsive disorder / treatment / cognitive behavioral therapy / treatment resistance / treatment efficacy / predictors.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle Obsessive-compulsive disorder / treatment / cognitive behavioral therapy / treatment resistance / treatment efficacy / predictors.
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Vyskocilova J
Prasko J
Sipek J
Cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder
description Jana Vyskocilova,1 Jan Prasko,2 Jiri Sipek3 1Faculty of Humanities, Charles University in Prague, Prague, 2Department of Psychiatry, Faculty of Medicine and Dentistry, Palacky University Olomouc, University Hospital Olomouc, Olomouc, 3Department of Psychology, Faculty of Arts, Charles University in Prague, Prague, Czech Republic Background: The aim of the study was to determine whether patients with obsessive–compulsive disorder (OCD) resistant to drug therapy may improve their condition using intensive, systematic cognitive behavioral therapy (CBT) lasting for 6 weeks, and whether it is possible to predict the therapeutic effect using demographic, clinical, and selected psychological characteristics at baseline. Methods: Sixty-six OCD patients were included in the study, of which 57 completed the program. The diagnosis was confirmed using the structured Mini International Neuropsychiatric Interview. Patients were rated using the objective and subjective forms of the Yale–Brown Obsessive Compulsive Scale, objective and subjective forms of the Clinical Global Impression, Beck Anxiety Inventory, Beck Depression Inventory, Dissociative Experiences Scale, 20-item Somatoform Dissociation Questionnaire, and the Sheehan Disability Scale before their treatment, and with subjective Yale–Brown Obsessive Compulsive Scale, objective and subjective Clinical Global Impression, Beck Anxiety Inventory, and Beck Depression Inventory at the end of the treatment. Patients were treated with antidepressants and daily intensive group CBT for the 6-week period. Results: During the 6-week intensive CBT program in combination with pharmacotherapy, there was a significant improvement in patients suffering from OCD resistant to drug treatment. There were statistically significantly decrease in the scores assessing the severity of OCD symptoms, anxiety, and depressive feelings. A lower treatment effect was achieved specifically in patients who 1) showed fewer OCD themes in symptomatology, 2) showed a higher level of somatoform dissociation, 3) had poor insight, and 4) had a higher initial level of overall severity of the disorder. Remission of the disorder was more likely in patients who had 1) good insight, 2) a lower initial level of anxiety, and 3) no comorbid depressive disorder. Keywords: obsessive–compulsive disorder, treatment, cognitive behavioral therapy, treatment resistance, treatment efficacy, predictors
format article
author Vyskocilova J
Prasko J
Sipek J
author_facet Vyskocilova J
Prasko J
Sipek J
author_sort Vyskocilova J
title Cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder
title_short Cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder
title_full Cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder
title_fullStr Cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder
title_full_unstemmed Cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder
title_sort cognitive behavioral therapy in pharmacoresistant obsessive–compulsive disorder
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/d7f6c9661ea045999d8ff94c0c85161c
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