Curcubinoyl flavonoids from wild ginseng adventitious root cultures

Abstract Wild ginseng (Panax ginseng) adventitious root cultures were prepared by elicitation using methyl jasmonate and investigated further to find new secondary metabolites. Chromatographic fractionation of wild ginseng adventitious root cultures led to the isolation of eleven compounds. The chem...

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Autores principales:	Qing Liu, Seon Beom Kim, Yang Hee Jo, Jong Hoon Ahn, Ayman Turk, Da Eun Kim, Bo Yoon Chang, Sung Yeon Kim, Cheol-Seung Jeong, Bang Yeon Hwang, So-Young Park, Mi Kyeong Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7f723ff77a24e9699e396c52e3ba2af
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spelling	oai:doaj.org-article:d7f723ff77a24e9699e396c52e3ba2af2021-12-02T17:48:00ZCurcubinoyl flavonoids from wild ginseng adventitious root cultures10.1038/s41598-021-91850-82045-2322https://doaj.org/article/d7f723ff77a24e9699e396c52e3ba2af2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91850-8https://doaj.org/toc/2045-2322Abstract Wild ginseng (Panax ginseng) adventitious root cultures were prepared by elicitation using methyl jasmonate and investigated further to find new secondary metabolites. Chromatographic fractionation of wild ginseng adventitious root cultures led to the isolation of eleven compounds. The chemical structures of isolated compounds were identified as four known flavanone derivatives (1–4), one new curcubinoyl derivative, jasmogin A (5) and six new curcubinoyl-flavanone conjugates, jasmoflagins A-F (6–11) by extensive spectroscopic analysis. Newly isolated curcubinoyl derivatives showed inhibitory activity against lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages. Therefore, our present study suggested that elicitor stimulated plant cell cultures might contribute to the production of new metabolites.Qing LiuSeon Beom KimYang Hee JoJong Hoon AhnAyman TurkDa Eun KimBo Yoon ChangSung Yeon KimCheol-Seung JeongBang Yeon HwangSo-Young ParkMi Kyeong LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qing Liu Seon Beom Kim Yang Hee Jo Jong Hoon Ahn Ayman Turk Da Eun Kim Bo Yoon Chang Sung Yeon Kim Cheol-Seung Jeong Bang Yeon Hwang So-Young Park Mi Kyeong Lee Curcubinoyl flavonoids from wild ginseng adventitious root cultures
description	Abstract Wild ginseng (Panax ginseng) adventitious root cultures were prepared by elicitation using methyl jasmonate and investigated further to find new secondary metabolites. Chromatographic fractionation of wild ginseng adventitious root cultures led to the isolation of eleven compounds. The chemical structures of isolated compounds were identified as four known flavanone derivatives (1–4), one new curcubinoyl derivative, jasmogin A (5) and six new curcubinoyl-flavanone conjugates, jasmoflagins A-F (6–11) by extensive spectroscopic analysis. Newly isolated curcubinoyl derivatives showed inhibitory activity against lipopolysaccharide-stimulated nitric oxide production in RAW 264.7 macrophages. Therefore, our present study suggested that elicitor stimulated plant cell cultures might contribute to the production of new metabolites.
format	article
author	Qing Liu Seon Beom Kim Yang Hee Jo Jong Hoon Ahn Ayman Turk Da Eun Kim Bo Yoon Chang Sung Yeon Kim Cheol-Seung Jeong Bang Yeon Hwang So-Young Park Mi Kyeong Lee
author_facet	Qing Liu Seon Beom Kim Yang Hee Jo Jong Hoon Ahn Ayman Turk Da Eun Kim Bo Yoon Chang Sung Yeon Kim Cheol-Seung Jeong Bang Yeon Hwang So-Young Park Mi Kyeong Lee
author_sort	Qing Liu
title	Curcubinoyl flavonoids from wild ginseng adventitious root cultures
title_short	Curcubinoyl flavonoids from wild ginseng adventitious root cultures
title_full	Curcubinoyl flavonoids from wild ginseng adventitious root cultures
title_fullStr	Curcubinoyl flavonoids from wild ginseng adventitious root cultures
title_full_unstemmed	Curcubinoyl flavonoids from wild ginseng adventitious root cultures
title_sort	curcubinoyl flavonoids from wild ginseng adventitious root cultures
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d7f723ff77a24e9699e396c52e3ba2af
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Curcubinoyl flavonoids from wild ginseng adventitious root cultures

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