Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

Abstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Emanuel E. Canfora, Christina M. van der Beek, Johan W. E. Jocken, Gijs H. Goossens, Jens J. Holst, Steven W. M. Olde Damink, Kaatje Lenaerts, Cornelis H. C. Dejong, Ellen E. Blaak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d7f9135a3f5341078c8efaf7cc64e954
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d7f9135a3f5341078c8efaf7cc64e954
record_format	dspace
spelling	oai:doaj.org-article:d7f9135a3f5341078c8efaf7cc64e9542021-12-02T12:32:46ZColonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial10.1038/s41598-017-02546-x2045-2322https://doaj.org/article/d7f9135a3f5341078c8efaf7cc64e9542017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02546-xhttps://doaj.org/toc/2045-2322Abstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m2) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.Emanuel E. CanforaChristina M. van der BeekJohan W. E. JockenGijs H. GoossensJens J. HolstSteven W. M. Olde DaminkKaatje LenaertsCornelis H. C. DejongEllen E. BlaakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emanuel E. Canfora Christina M. van der Beek Johan W. E. Jocken Gijs H. Goossens Jens J. Holst Steven W. M. Olde Damink Kaatje Lenaerts Cornelis H. C. Dejong Ellen E. Blaak Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
description	Abstract Short-chain fatty acids (SCFA), formed by microbial fermentation, are believed to be involved in the aetiology of obesity and diabetes. This study investigated the effects of colonic administration of physiologically relevant SCFA mixtures on human substrate and energy metabolism. In this randomized, double-blind, crossover study, twelve normoglycaemic men (BMI 25–35 kg/m2) underwent four investigational days, during which SCFA mixtures (200 mmol/L) high in either acetate (HA), propionate (HP), butyrate (HB) or placebo (PLA) were rectally administered during fasting and postprandial conditions (oral glucose load). Before and for two hours after colonic infusions, indirect calorimetry was performed and blood samples were collected. All three SCFA mixtures increased fasting fat oxidation (P < 0.01), whilst resting energy expenditure increased after HA and HP compared with PLA (P < 0.05). In addition, all three SCFA mixtures increased fasting and postprandial plasma peptide YY (PYY) concentrations, and attenuated fasting free glycerol concentrations versus PLA (P < 0.05). Colonic infusions of SCFA mixtures, in concentrations and ratios reached after fibre intake, increased fat oxidation, energy expenditure and PYY, and decreased lipolysis in overweight/obese men. Human intervention studies are warranted to investigate whether these effects translate into long-term benefits for body weight control and insulin sensitivity in the obese insulin resistant state.
format	article
author	Emanuel E. Canfora Christina M. van der Beek Johan W. E. Jocken Gijs H. Goossens Jens J. Holst Steven W. M. Olde Damink Kaatje Lenaerts Cornelis H. C. Dejong Ellen E. Blaak
author_facet	Emanuel E. Canfora Christina M. van der Beek Johan W. E. Jocken Gijs H. Goossens Jens J. Holst Steven W. M. Olde Damink Kaatje Lenaerts Cornelis H. C. Dejong Ellen E. Blaak
author_sort	Emanuel E. Canfora
title	Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
title_short	Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
title_full	Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
title_fullStr	Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
title_full_unstemmed	Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
title_sort	colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d7f9135a3f5341078c8efaf7cc64e954
work_keys_str_mv	AT emanuelecanfora colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT christinamvanderbeek colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT johanwejocken colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT gijshgoossens colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT jensjholst colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT stevenwmoldedamink colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT kaatjelenaerts colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT cornelishcdejong colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial AT elleneblaak colonicinfusionsofshortchainfattyacidmixturespromoteenergymetabolisminoverweightobesemenarandomizedcrossovertrial
_version_	1718394009472204800

Colonic infusions of short-chain fatty acid mixtures promote energy metabolism in overweight/obese men: a randomized crossover trial

Ejemplares similares