Biomedical Applications of Translational Optical Imaging: From Molecules to Humans

Light is a powerful investigational tool in biomedicine, at all levels of structural organization. Its multitude of features (intensity, wavelength, polarization, interference, coherence, timing, non-linear absorption, and even interactions with itself) able to create contrast, and thus images that...

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Autor principal:	Daniel L. Farkas
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	optical bioimaging spectral multimode superresolution microscopy in vivo coherence Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/d7f9b043ec874e1fbb03e0ba57dad2b8
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spelling	oai:doaj.org-article:d7f9b043ec874e1fbb03e0ba57dad2b82021-11-11T18:37:09ZBiomedical Applications of Translational Optical Imaging: From Molecules to Humans10.3390/molecules262166511420-3049https://doaj.org/article/d7f9b043ec874e1fbb03e0ba57dad2b82021-11-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6651https://doaj.org/toc/1420-3049Light is a powerful investigational tool in biomedicine, at all levels of structural organization. Its multitude of features (intensity, wavelength, polarization, interference, coherence, timing, non-linear absorption, and even interactions with itself) able to create contrast, and thus images that detail the makeup and functioning of the living state can and should be combined for maximum effect, especially if one seeks simultaneously high spatiotemporal resolution and discrimination ability within a living organism. The resulting high relevance should be directed towards a better understanding, detection of abnormalities, and ultimately cogent, precise, and effective intervention. The new optical methods and their combinations needed to address modern surgery in the operating room of the future, and major diseases such as cancer and neurodegeneration are reviewed here, with emphasis on our own work and highlighting selected applications focusing on quantitation, early detection, treatment assessment, and clinical relevance, and more generally matching the quality of the optical detection approach to the complexity of the disease. This should provide guidance for future advanced theranostics, emphasizing a tighter coupling—spatially and temporally—between detection, diagnosis, and treatment, in the hope that technologic sophistication such as that of a Mars rover can be translationally deployed in the clinic, for saving and improving lives.Daniel L. FarkasMDPI AGarticleoptical bioimagingspectralmultimodesuperresolution microscopyin vivocoherenceOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6651, p 6651 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	optical bioimaging spectral multimode superresolution microscopy in vivo coherence Organic chemistry QD241-441
spellingShingle	optical bioimaging spectral multimode superresolution microscopy in vivo coherence Organic chemistry QD241-441 Daniel L. Farkas Biomedical Applications of Translational Optical Imaging: From Molecules to Humans
description	Light is a powerful investigational tool in biomedicine, at all levels of structural organization. Its multitude of features (intensity, wavelength, polarization, interference, coherence, timing, non-linear absorption, and even interactions with itself) able to create contrast, and thus images that detail the makeup and functioning of the living state can and should be combined for maximum effect, especially if one seeks simultaneously high spatiotemporal resolution and discrimination ability within a living organism. The resulting high relevance should be directed towards a better understanding, detection of abnormalities, and ultimately cogent, precise, and effective intervention. The new optical methods and their combinations needed to address modern surgery in the operating room of the future, and major diseases such as cancer and neurodegeneration are reviewed here, with emphasis on our own work and highlighting selected applications focusing on quantitation, early detection, treatment assessment, and clinical relevance, and more generally matching the quality of the optical detection approach to the complexity of the disease. This should provide guidance for future advanced theranostics, emphasizing a tighter coupling—spatially and temporally—between detection, diagnosis, and treatment, in the hope that technologic sophistication such as that of a Mars rover can be translationally deployed in the clinic, for saving and improving lives.
format	article
author	Daniel L. Farkas
author_facet	Daniel L. Farkas
author_sort	Daniel L. Farkas
title	Biomedical Applications of Translational Optical Imaging: From Molecules to Humans
title_short	Biomedical Applications of Translational Optical Imaging: From Molecules to Humans
title_full	Biomedical Applications of Translational Optical Imaging: From Molecules to Humans
title_fullStr	Biomedical Applications of Translational Optical Imaging: From Molecules to Humans
title_full_unstemmed	Biomedical Applications of Translational Optical Imaging: From Molecules to Humans
title_sort	biomedical applications of translational optical imaging: from molecules to humans
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d7f9b043ec874e1fbb03e0ba57dad2b8
work_keys_str_mv	AT daniellfarkas biomedicalapplicationsoftranslationalopticalimagingfrommoleculestohumans
_version_	1718431791007662080

Biomedical Applications of Translational Optical Imaging: From Molecules to Humans

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