p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.

p16( INK4a) positively regulates cyclin D1 and E2F1 through negative control of AUF1.

<h4>Background</h4>The cyclin-D/CDK4,6/p16(INK4a)/pRB/E2F pathway, a key regulator of the critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. However, the precise function of the different members of this pathway and their functional interplay a...

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Autores principales: Huda H Al-Khalaf, Dilek Colak, Maher Al-Saif, Albandary Al-Bakheet, Siti-Faujiah Hendrayani, Nujoud Al-Yousef, Namik Kaya, Khalid S Khabar, Abdelilah Aboussekhra
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d7f9ff83f9be405ab2aa0df2055b4300
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