Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.

Widespread FRA1-dependent control of mesenchymal transdifferentiation programs in colorectal cancer cells.

Tumor invasion and metastasis involves complex remodeling of gene expression programs governing epithelial homeostasis. Mutational activation of the RAS-ERK is a frequent occurrence in many cancers and has been shown to drive overexpression of the AP-1 family transcription factor FRA1, a potent regu...

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Autores principales: Jeannine Diesch, Elaine Sanij, Omer Gilan, Christopher Love, Hoanh Tran, Nicholas I Fleming, Jason Ellul, Marcia Amalia, Izhak Haviv, Richard B Pearson, Eugene Tulchinsky, John M Mariadason, Oliver M Sieber, Ross D Hannan, Amardeep S Dhillon
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/d7fe9ee98a4f408bb231db36ea198d14
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