Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradabi...

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Autores principales:	Anand Mohan, Madhuri Girdhar, Raj Kumar, Harshil S. Chaturvedi, Agrataben Vadhel, Pratima R. Solanki, Anil Kumar, Deepak Kumar, Narsimha Mamidi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	nanocomposite tissue engineering nano-clay nanoblend biomedical technology polyhydroxy butyrate Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d8014a6a454546ed88dafdc35f00e3a6
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spelling	oai:doaj.org-article:d8014a6a454546ed88dafdc35f00e3a62021-11-25T18:39:51ZPolyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering10.3390/ph141111631424-8247https://doaj.org/article/d8014a6a454546ed88dafdc35f00e3a62021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1163https://doaj.org/toc/1424-8247Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradability. However, PHB use in bone tissue engineering is limited due to its inadequate physicochemical and mechanical properties. In the present work, we synthesized PHB-based nanocomposites using a nanoblend and nano-clay with modified montmorillonite (MMT) as a filler. MMT was modified using trimethyl stearyl ammonium (TMSA). Nanoblend and nano-clay were fabricated using the solvent-casting technique. Inspection of the composite structure revealed that the basal spacing of the polymeric matrix material was significantly altered depending on the loading percentage of organically modified montmorillonite (OMMT) nano-clay. The PHB/OMMT nanocomposite displayed enhanced thermal stability and upper working temperature upon heating as compared to the pristine polymer. The dispersed (OMMT) nano-clay assisted in the formation of pores on the surface of the polymer. The pore size was proportional to the weight percentage of OMMT. Further morphological analysis of these blends was carried out through FESEM. The obtained nanocomposites exhibited augmented properties over neat PHB and could have an abundance of applications in the industry and medicinal sectors. In particular, improved porosity, non-immunogenic nature, and strong biocompatibility suggest their effective application in bone tissue engineering. Thus, PHB/OMMT nanocomposites are a promising candidate for 3D organ printing, lab-on-a-chip scaffold engineering, and bone tissue engineering.Anand MohanMadhuri GirdharRaj KumarHarshil S. ChaturvediAgrataben VadhelPratima R. SolankiAnil KumarDeepak KumarNarsimha MamidiMDPI AGarticlenanocompositetissue engineeringnano-claynanoblendbiomedical technologypolyhydroxy butyrateMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1163, p 1163 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanocomposite tissue engineering nano-clay nanoblend biomedical technology polyhydroxy butyrate Medicine R Pharmacy and materia medica RS1-441
spellingShingle	nanocomposite tissue engineering nano-clay nanoblend biomedical technology polyhydroxy butyrate Medicine R Pharmacy and materia medica RS1-441 Anand Mohan Madhuri Girdhar Raj Kumar Harshil S. Chaturvedi Agrataben Vadhel Pratima R. Solanki Anil Kumar Deepak Kumar Narsimha Mamidi Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering
description	Bone-related diseases have been increasing worldwide, and several nanocomposites have been used to treat them. Among several nanocomposites, polyhydroxybutyrate (PHB)-based nanocomposites are widely used in drug delivery and tissue engineering due to their excellent biocompatibility and biodegradability. However, PHB use in bone tissue engineering is limited due to its inadequate physicochemical and mechanical properties. In the present work, we synthesized PHB-based nanocomposites using a nanoblend and nano-clay with modified montmorillonite (MMT) as a filler. MMT was modified using trimethyl stearyl ammonium (TMSA). Nanoblend and nano-clay were fabricated using the solvent-casting technique. Inspection of the composite structure revealed that the basal spacing of the polymeric matrix material was significantly altered depending on the loading percentage of organically modified montmorillonite (OMMT) nano-clay. The PHB/OMMT nanocomposite displayed enhanced thermal stability and upper working temperature upon heating as compared to the pristine polymer. The dispersed (OMMT) nano-clay assisted in the formation of pores on the surface of the polymer. The pore size was proportional to the weight percentage of OMMT. Further morphological analysis of these blends was carried out through FESEM. The obtained nanocomposites exhibited augmented properties over neat PHB and could have an abundance of applications in the industry and medicinal sectors. In particular, improved porosity, non-immunogenic nature, and strong biocompatibility suggest their effective application in bone tissue engineering. Thus, PHB/OMMT nanocomposites are a promising candidate for 3D organ printing, lab-on-a-chip scaffold engineering, and bone tissue engineering.
format	article
author	Anand Mohan Madhuri Girdhar Raj Kumar Harshil S. Chaturvedi Agrataben Vadhel Pratima R. Solanki Anil Kumar Deepak Kumar Narsimha Mamidi
author_facet	Anand Mohan Madhuri Girdhar Raj Kumar Harshil S. Chaturvedi Agrataben Vadhel Pratima R. Solanki Anil Kumar Deepak Kumar Narsimha Mamidi
author_sort	Anand Mohan
title	Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering
title_short	Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering
title_full	Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering
title_fullStr	Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering
title_full_unstemmed	Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering
title_sort	polyhydroxybutyrate-based nanocomposites for bone tissue engineering
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d8014a6a454546ed88dafdc35f00e3a6
work_keys_str_mv	AT anandmohan polyhydroxybutyratebasednanocompositesforbonetissueengineering AT madhurigirdhar polyhydroxybutyratebasednanocompositesforbonetissueengineering AT rajkumar polyhydroxybutyratebasednanocompositesforbonetissueengineering AT harshilschaturvedi polyhydroxybutyratebasednanocompositesforbonetissueengineering AT agratabenvadhel polyhydroxybutyratebasednanocompositesforbonetissueengineering AT pratimarsolanki polyhydroxybutyratebasednanocompositesforbonetissueengineering AT anilkumar polyhydroxybutyratebasednanocompositesforbonetissueengineering AT deepakkumar polyhydroxybutyratebasednanocompositesforbonetissueengineering AT narsimhamamidi polyhydroxybutyratebasednanocompositesforbonetissueengineering
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Polyhydroxybutyrate-Based Nanocomposites for Bone Tissue Engineering

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