The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients

The cytochrome 11B2 aldosterone synthase gene rs1799998 single nucleotide polymorphism determines elevated aldosterone, higher blood pressure, and reduced glomerular filtration, especially in diabetic female patients

Objective. The cytochrome 11B2 aldosterone synthase gene (CYP11B2) that links to aldosterone synthase enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes.

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Auteurs principaux: Sydorchuk Larysa, Dzhuryak Valentina, Sydorchuk Andrii, Levytska Svitlana, Petrynych Volodymyr, Knut Ruslan, Kshanovska Anna, Iftoda Oksana, Tkachuk Olexii, Kyfiak Petro, Popovich Andrii, Khomko Oleh, Sydorchuk Ruslan
Format: article
Langue:EN
Publié: Sciendo 2020
Sujets:
cyp11b2 (rs1799998) gene
aldosterone
chronic kidney disease
hypertension
diabetes
Diseases of the endocrine glands. Clinical endocrinology
RC648-665
Accès en ligne:https://doaj.org/article/d8153d99f41c4545b934d85eeae746e5
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Résumé:Objective. The cytochrome 11B2 aldosterone synthase gene (CYP11B2) that links to aldosterone synthase enzyme synthesis changes and blood pressure regulation is of particular interest among the renin-angiotensin-aldosterone system encoding genes.

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