An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate peptide half-lives and receptor activation properti...

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Autores principales:	Thomas D. Madsen, Lasse H. Hansen, John Hintze, Zilu Ye, Shifa Jebari, Daniel B. Andersen, Hiren J. Joshi, Tongzhong Ju, Jens P. Goetze, Cesar Martin, Mette M. Rosenkilde, Jens J. Holst, Rune E. Kuhre, Christoffer K. Goth, Sergey Y. Vakhrushev, Katrine T. Schjoldager
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d81560792a8349198626ee05e6f9d81f
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spelling	oai:doaj.org-article:d81560792a8349198626ee05e6f9d81f2021-12-02T16:45:56ZAn atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles10.1038/s41467-020-17473-12041-1723https://doaj.org/article/d81560792a8349198626ee05e6f9d81f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17473-1https://doaj.org/toc/2041-1723O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate peptide half-lives and receptor activation properties.Thomas D. MadsenLasse H. HansenJohn HintzeZilu YeShifa JebariDaniel B. AndersenHiren J. JoshiTongzhong JuJens P. GoetzeCesar MartinMette M. RosenkildeJens J. HolstRune E. KuhreChristoffer K. GothSergey Y. VakhrushevKatrine T. SchjoldagerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Thomas D. Madsen Lasse H. Hansen John Hintze Zilu Ye Shifa Jebari Daniel B. Andersen Hiren J. Joshi Tongzhong Ju Jens P. Goetze Cesar Martin Mette M. Rosenkilde Jens J. Holst Rune E. Kuhre Christoffer K. Goth Sergey Y. Vakhrushev Katrine T. Schjoldager An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
description	O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate peptide half-lives and receptor activation properties.
format	article
author	Thomas D. Madsen Lasse H. Hansen John Hintze Zilu Ye Shifa Jebari Daniel B. Andersen Hiren J. Joshi Tongzhong Ju Jens P. Goetze Cesar Martin Mette M. Rosenkilde Jens J. Holst Rune E. Kuhre Christoffer K. Goth Sergey Y. Vakhrushev Katrine T. Schjoldager
author_facet	Thomas D. Madsen Lasse H. Hansen John Hintze Zilu Ye Shifa Jebari Daniel B. Andersen Hiren J. Joshi Tongzhong Ju Jens P. Goetze Cesar Martin Mette M. Rosenkilde Jens J. Holst Rune E. Kuhre Christoffer K. Goth Sergey Y. Vakhrushev Katrine T. Schjoldager
author_sort	Thomas D. Madsen
title	An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
title_short	An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
title_full	An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
title_fullStr	An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
title_full_unstemmed	An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
title_sort	atlas of o-linked glycosylation on peptide hormones reveals diverse biological roles
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d81560792a8349198626ee05e6f9d81f
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An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

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