Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.

Treatment strategies blocking tumor necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA), showing beneficial effects in approximately 50-60% of the patients. However, a significant subset of patients does not respond to anti-TNF agents, for reasons that a...

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Autores principales:	Maria I Zervou, Efsevia Myrthianou, Irene Flouri, Darren Plant, Gregory Chlouverakis, Francesc Castro-Giner, Panayiota Rapsomaniki, Anne Barton, Dimitrios T Boumpas, Prodromos Sidiropoulos, George N Goulielmos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d815bff146db47889e607f6a9e99c7ec
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spelling	oai:doaj.org-article:d815bff146db47889e607f6a9e99c7ec2021-11-18T08:55:58ZLack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.1932-620310.1371/journal.pone.0074375https://doaj.org/article/d815bff146db47889e607f6a9e99c7ec2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24040234/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Treatment strategies blocking tumor necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA), showing beneficial effects in approximately 50-60% of the patients. However, a significant subset of patients does not respond to anti-TNF agents, for reasons that are still unknown. The aim of this study was to validate five single nucleotide polymorphisms (SNPs) of PTPRC, CD226, AFF3, MyD88 and CHUK gene loci that have previously been reported to predict anti-TNF outcome. In addition, two markers of RA susceptibility, namely TRAF1/C5 and STAT4 were assessed, in a cohort of anti-TNF-treated RA patients, from the homogeneous Greek island of Crete, Greece. The RA patient cohort consisted of 183 patients treated with either of 3 anti-TNF biologic agents (infliximab, adalimumab and etanercept) from the Clinic of Rheumatology of the University Hospital of Crete. The SNPs were genotyped by TaqMan assays or following the Restriction Fragments Length Polymorphisms (RFLPs) approach. Disease activity score in 28 joints (DAS28) at baseline and after 6 months were available for all patients and analysis of good versus poor response at 6 months was performed for each SNP. None of the 7 genetic markers correlated with treatment response. We conclude that the gene polymorphisms under investigation are not strongly predictive of anti-TNF response in RA patients from Greece.Maria I ZervouEfsevia MyrthianouIrene FlouriDarren PlantGregory ChlouverakisFrancesc Castro-GinerPanayiota RapsomanikiAnne BartonDimitrios T BoumpasProdromos SidiropoulosGeorge N GoulielmosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74375 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maria I Zervou Efsevia Myrthianou Irene Flouri Darren Plant Gregory Chlouverakis Francesc Castro-Giner Panayiota Rapsomaniki Anne Barton Dimitrios T Boumpas Prodromos Sidiropoulos George N Goulielmos Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.
description	Treatment strategies blocking tumor necrosis factor (anti-TNF) have proven very successful in patients with rheumatoid arthritis (RA), showing beneficial effects in approximately 50-60% of the patients. However, a significant subset of patients does not respond to anti-TNF agents, for reasons that are still unknown. The aim of this study was to validate five single nucleotide polymorphisms (SNPs) of PTPRC, CD226, AFF3, MyD88 and CHUK gene loci that have previously been reported to predict anti-TNF outcome. In addition, two markers of RA susceptibility, namely TRAF1/C5 and STAT4 were assessed, in a cohort of anti-TNF-treated RA patients, from the homogeneous Greek island of Crete, Greece. The RA patient cohort consisted of 183 patients treated with either of 3 anti-TNF biologic agents (infliximab, adalimumab and etanercept) from the Clinic of Rheumatology of the University Hospital of Crete. The SNPs were genotyped by TaqMan assays or following the Restriction Fragments Length Polymorphisms (RFLPs) approach. Disease activity score in 28 joints (DAS28) at baseline and after 6 months were available for all patients and analysis of good versus poor response at 6 months was performed for each SNP. None of the 7 genetic markers correlated with treatment response. We conclude that the gene polymorphisms under investigation are not strongly predictive of anti-TNF response in RA patients from Greece.
format	article
author	Maria I Zervou Efsevia Myrthianou Irene Flouri Darren Plant Gregory Chlouverakis Francesc Castro-Giner Panayiota Rapsomaniki Anne Barton Dimitrios T Boumpas Prodromos Sidiropoulos George N Goulielmos
author_facet	Maria I Zervou Efsevia Myrthianou Irene Flouri Darren Plant Gregory Chlouverakis Francesc Castro-Giner Panayiota Rapsomaniki Anne Barton Dimitrios T Boumpas Prodromos Sidiropoulos George N Goulielmos
author_sort	Maria I Zervou
title	Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.
title_short	Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.
title_full	Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.
title_fullStr	Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.
title_full_unstemmed	Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.
title_sort	lack of association of variants previously associated with anti-tnf medication response in rheumatoid arthritis patients: results from a homogeneous greek population.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/d815bff146db47889e607f6a9e99c7ec
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Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population.

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