Chronomics, human time estimation, and aging

Franz Halberg, Robert B Sothern, Germaine Cornélissen, Jerzy Czaplicki1Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA; 1Institut de Pharmacologie et de Biologie Structurale CNRS, Université Paul Sabatier, Toulouse, FranceBackground: Circadian rhythm...

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Autores principales:	Franz Halberg, Robert B Sothern, Germaine Cornélissen, Jerzy Czaplicki
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	circadian rhythm mental function time estimation Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/d818bd4c8d2545c0bea8566d8a75572e
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spelling	oai:doaj.org-article:d818bd4c8d2545c0bea8566d8a75572e2021-12-02T07:30:00ZChronomics, human time estimation, and aging1178-1998https://doaj.org/article/d818bd4c8d2545c0bea8566d8a75572e2008-12-01T00:00:00Zhttps://www.dovepress.com/chronomics-human-time-estimation-and-aging-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Franz Halberg, Robert B Sothern, Germaine Cornélissen, Jerzy Czaplicki1Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA; 1Institut de Pharmacologie et de Biologie Structurale CNRS, Université Paul Sabatier, Toulouse, FranceBackground: Circadian rhythm stage affects many outcomes, including those of mental aging.Methods: Estimations of 1 minute &sim;5 times/day for a year, 25 years apart, by a healthy male biomedical scientist (RBS), are analyzed by the extended cosinor.Results: Cycles of a half-week, a week, &sim;30 days, a half-year and a year, in self-assessed 1-minute estimation by RBS between 25 and 60 years of age in health, are mapped for the first time, compared and opposite effects are found. For RBS at 60 vs at 25 years of age, it takes less time in the morning around 10:30 (P < 0.001), but not in the evening around 19:30 (P = 0.956), to estimate 1 minute.Discussion: During the intervening decades, the time of estimating 1 minute differed greatly, dependent on circadian stage, being a linear decrease in the morning and increase in the evening, the latter modulated by a &sim;33.6-year cycle.Conclusion: Circadian and infradian rhythm mapping is essential for a scrutiny of effects of aging. A &sim;30-day and a circannual component apparent at 25 years of age are not found later; cycles longer than a year are detected. Rhythm stages await tests as markers for timing therapy in disease.Keywords: circadian rhythm, mental function, time estimationFranz HalbergRobert B SothernGermaine CornélissenJerzy CzaplickiDove Medical Pressarticlecircadian rhythmmental functiontime estimationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 749-760 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	circadian rhythm mental function time estimation Geriatrics RC952-954.6
spellingShingle	circadian rhythm mental function time estimation Geriatrics RC952-954.6 Franz Halberg Robert B Sothern Germaine Cornélissen Jerzy Czaplicki Chronomics, human time estimation, and aging
description	Franz Halberg, Robert B Sothern, Germaine Cornélissen, Jerzy Czaplicki1Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA; 1Institut de Pharmacologie et de Biologie Structurale CNRS, Université Paul Sabatier, Toulouse, FranceBackground: Circadian rhythm stage affects many outcomes, including those of mental aging.Methods: Estimations of 1 minute &sim;5 times/day for a year, 25 years apart, by a healthy male biomedical scientist (RBS), are analyzed by the extended cosinor.Results: Cycles of a half-week, a week, &sim;30 days, a half-year and a year, in self-assessed 1-minute estimation by RBS between 25 and 60 years of age in health, are mapped for the first time, compared and opposite effects are found. For RBS at 60 vs at 25 years of age, it takes less time in the morning around 10:30 (P < 0.001), but not in the evening around 19:30 (P = 0.956), to estimate 1 minute.Discussion: During the intervening decades, the time of estimating 1 minute differed greatly, dependent on circadian stage, being a linear decrease in the morning and increase in the evening, the latter modulated by a &sim;33.6-year cycle.Conclusion: Circadian and infradian rhythm mapping is essential for a scrutiny of effects of aging. A &sim;30-day and a circannual component apparent at 25 years of age are not found later; cycles longer than a year are detected. Rhythm stages await tests as markers for timing therapy in disease.Keywords: circadian rhythm, mental function, time estimation
format	article
author	Franz Halberg Robert B Sothern Germaine Cornélissen Jerzy Czaplicki
author_facet	Franz Halberg Robert B Sothern Germaine Cornélissen Jerzy Czaplicki
author_sort	Franz Halberg
title	Chronomics, human time estimation, and aging
title_short	Chronomics, human time estimation, and aging
title_full	Chronomics, human time estimation, and aging
title_fullStr	Chronomics, human time estimation, and aging
title_full_unstemmed	Chronomics, human time estimation, and aging
title_sort	chronomics, human time estimation, and aging
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/d818bd4c8d2545c0bea8566d8a75572e
work_keys_str_mv	AT franzhalberg chronomicshumantimeestimationandaging AT robertbsothern chronomicshumantimeestimationandaging AT germainecorneacutelissen chronomicshumantimeestimationandaging AT jerzyczaplicki chronomicshumantimeestimationandaging
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Chronomics, human time estimation, and aging

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