THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY

The transmembrane CD200 glycoprotein belongs to the immunoglobulin family and it is widely represented on a variety of cell types, while its structurally similar CD200R receptor is expressed, mainly, on myeloid and lymphoid cells. An immunomodulatory role of CD200 and CD200R interaction is to activa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. S. Arefieva, A. A. Babayan, E. O. Stepanova, T. V. Dontsova, S. V. Pavlovich, L. V. Krechetova, M. A. Nikolaeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	cd200 allograft pregnancy immune tolerance inhibitory receptor recurrent abortion Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/d81946e3ee84422796817f0a9bd63b6b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d81946e3ee84422796817f0a9bd63b6b
record_format	dspace
spelling	oai:doaj.org-article:d81946e3ee84422796817f0a9bd63b6b2021-11-18T08:03:47ZTHE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY1563-06252313-741X10.15789/1563-0625-2018-6-807-814https://doaj.org/article/d81946e3ee84422796817f0a9bd63b6b2018-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1665https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe transmembrane CD200 glycoprotein belongs to the immunoglobulin family and it is widely represented on a variety of cell types, while its structurally similar CD200R receptor is expressed, mainly, on myeloid and lymphoid cells. An immunomodulatory role of CD200 and CD200R interaction is to activate the intracellular inhibitory cascade of reactions, leading to suppression of effector immune cells and attenuation of the inflammatory process. Thus, the CD200R activation stimulates the differentiation of naive T cells to regulatory T cells, increasing the indolamine 2,3-dioxygenase activity, and enhances the synthesis of IL-10 and TGF-β cytokines, contributing to development of a Th2-dependent anti-inflammatory environment. These immune regulatory events provide the development of immune tolerance and are required for controlling the development of autoimmune processes, hypersensitivity, engraftment of transplanted organs and tissues, as well as protecting the fetus from spontaneous abortion. Tolerogenic potential of interaction between CD200 and CD200R molecules can be effectively used for treatment of various diseases (e.g., Alzheimer’s, rheumatoid arthritis, allergies). In this review, we will address the role of CD200/CD200R interactions in stimulating the post-transplant engraftment and protecting a fetus from spontaneous abortion. Many in vivo and in vitro studies have suggested a key role of CD200/CD200R interaction in immune maintenance of both processes.A. S. ArefievaA. A. BabayanE. O. StepanovaT. V. DontsovaS. V. PavlovichL. V. KrechetovaM. A. NikolaevaSPb RAACIarticlecd200allograftpregnancyimmune toleranceinhibitory receptorrecurrent abortionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 6, Pp 807-814 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	cd200 allograft pregnancy immune tolerance inhibitory receptor recurrent abortion Immunologic diseases. Allergy RC581-607
spellingShingle	cd200 allograft pregnancy immune tolerance inhibitory receptor recurrent abortion Immunologic diseases. Allergy RC581-607 A. S. Arefieva A. A. Babayan E. O. Stepanova T. V. Dontsova S. V. Pavlovich L. V. Krechetova M. A. Nikolaeva THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY
description	The transmembrane CD200 glycoprotein belongs to the immunoglobulin family and it is widely represented on a variety of cell types, while its structurally similar CD200R receptor is expressed, mainly, on myeloid and lymphoid cells. An immunomodulatory role of CD200 and CD200R interaction is to activate the intracellular inhibitory cascade of reactions, leading to suppression of effector immune cells and attenuation of the inflammatory process. Thus, the CD200R activation stimulates the differentiation of naive T cells to regulatory T cells, increasing the indolamine 2,3-dioxygenase activity, and enhances the synthesis of IL-10 and TGF-β cytokines, contributing to development of a Th2-dependent anti-inflammatory environment. These immune regulatory events provide the development of immune tolerance and are required for controlling the development of autoimmune processes, hypersensitivity, engraftment of transplanted organs and tissues, as well as protecting the fetus from spontaneous abortion. Tolerogenic potential of interaction between CD200 and CD200R molecules can be effectively used for treatment of various diseases (e.g., Alzheimer’s, rheumatoid arthritis, allergies). In this review, we will address the role of CD200/CD200R interactions in stimulating the post-transplant engraftment and protecting a fetus from spontaneous abortion. Many in vivo and in vitro studies have suggested a key role of CD200/CD200R interaction in immune maintenance of both processes.
format	article
author	A. S. Arefieva A. A. Babayan E. O. Stepanova T. V. Dontsova S. V. Pavlovich L. V. Krechetova M. A. Nikolaeva
author_facet	A. S. Arefieva A. A. Babayan E. O. Stepanova T. V. Dontsova S. V. Pavlovich L. V. Krechetova M. A. Nikolaeva
author_sort	A. S. Arefieva
title	THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY
title_short	THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY
title_full	THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY
title_fullStr	THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY
title_full_unstemmed	THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY
title_sort	role of cd200/cd200r interactions in the formation of immunological tolerance in transplantation and pregnancy
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/d81946e3ee84422796817f0a9bd63b6b
work_keys_str_mv	AT asarefieva theroleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT aababayan theroleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT eostepanova theroleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT tvdontsova theroleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT svpavlovich theroleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT lvkrechetova theroleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT manikolaeva theroleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT asarefieva roleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT aababayan roleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT eostepanova roleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT tvdontsova roleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT svpavlovich roleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT lvkrechetova roleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy AT manikolaeva roleofcd200cd200rinteractionsintheformationofimmunologicaltoleranceintransplantationandpregnancy
_version_	1718422384858365952

THE ROLE OF CD200/CD200R INTERACTIONS IN THE FORMATION OF IMMUNOLOGICAL TOLERANCE IN TRANSPLANTATION AND PREGNANCY

Ejemplares similares