Targeted Phenotypic Screening in <named-content content-type="genus-species">Plasmodium falciparum</named-content> and <named-content content-type="genus-species">Toxoplasma gondii</named-content> Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules

Targeted Phenotypic Screening in <named-content content-type="genus-species">Plasmodium falciparum</named-content> and <named-content content-type="genus-species">Toxoplasma gondii</named-content> Reveals Novel Modes of Action of Medicines for Malaria Venture Malaria Box Molecules

ABSTRACT The Malaria Box collection includes 400 chemically diverse small molecules with documented potency against malaria parasite growth, but the underlying modes of action are largely unknown. Using complementary phenotypic screens against Plasmodium falciparum and Toxoplasma gondii, we report p...

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Bibliographic Details
Main Authors: Gowtham Subramanian, Meenakshi A. Belekar, Anurag Shukla, Jie Xin Tong, Ameya Sinha, Trang T. T. Chu, Akshay S. Kulkarni, Peter R. Preiser, D. Srinivasa Reddy, Kevin S. W. Tan, Dhanasekaran Shanmugam, Rajesh Chandramohanadas
Format: article
Language:EN
Published: American Society for Microbiology 2018
Subjects:
MMV Malaria Box
malaria
Plasmodium falciparum
Toxoplasma gondii
apicoplast
chemical phenotyping
Microbiology
QR1-502
Online Access:https://doaj.org/article/d819bcc1aa584947876cb9484e9bb1d1
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