Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural crest cell differentiation that is impaired in...

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Autores principales:	Luca Pagliaroli, Patrizia Porazzi, Alyxandra T. Curtis, Chiara Scopa, Harald M. M. Mikkers, Christian Freund, Lucia Daxinger, Sandra Deliard, Sarah A. Welsh, Sarah Offley, Connor A. Ott, Bruno Calabretta, Samantha A. Brugmann, Gijs W. E. Santen, Marco Trizzino
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d81d9aec3d4b4606a4380fcc57816cd2
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spelling	oai:doaj.org-article:d81d9aec3d4b4606a4380fcc57816cd22021-11-14T12:35:58ZInability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders10.1038/s41467-021-26810-x2041-1723https://doaj.org/article/d81d9aec3d4b4606a4380fcc57816cd22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26810-xhttps://doaj.org/toc/2041-1723Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural crest cell differentiation that is impaired in Coffin-Siris patient-derived cells, which is important for exit from pluripotency.Luca PagliaroliPatrizia PorazziAlyxandra T. CurtisChiara ScopaHarald M. M. MikkersChristian FreundLucia DaxingerSandra DeliardSarah A. WelshSarah OffleyConnor A. OttBruno CalabrettaSamantha A. BrugmannGijs W. E. SantenMarco TrizzinoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luca Pagliaroli Patrizia Porazzi Alyxandra T. Curtis Chiara Scopa Harald M. M. Mikkers Christian Freund Lucia Daxinger Sandra Deliard Sarah A. Welsh Sarah Offley Connor A. Ott Bruno Calabretta Samantha A. Brugmann Gijs W. E. Santen Marco Trizzino Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
description	Mutations in the ARID1B subunit of the BAF chromatin remodeling complex are associated with the neurodevelopmental Coffin-Siris syndrome. Here the authors reveal that there is a transition from ARID1A-containing complexes to ARID1B during cranial neural crest cell differentiation that is impaired in Coffin-Siris patient-derived cells, which is important for exit from pluripotency.
format	article
author	Luca Pagliaroli Patrizia Porazzi Alyxandra T. Curtis Chiara Scopa Harald M. M. Mikkers Christian Freund Lucia Daxinger Sandra Deliard Sarah A. Welsh Sarah Offley Connor A. Ott Bruno Calabretta Samantha A. Brugmann Gijs W. E. Santen Marco Trizzino
author_facet	Luca Pagliaroli Patrizia Porazzi Alyxandra T. Curtis Chiara Scopa Harald M. M. Mikkers Christian Freund Lucia Daxinger Sandra Deliard Sarah A. Welsh Sarah Offley Connor A. Ott Bruno Calabretta Samantha A. Brugmann Gijs W. E. Santen Marco Trizzino
author_sort	Luca Pagliaroli
title	Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
title_short	Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
title_full	Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
title_fullStr	Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
title_full_unstemmed	Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders
title_sort	inability to switch from arid1a-baf to arid1b-baf impairs exit from pluripotency and commitment towards neural crest formation in arid1b-related neurodevelopmental disorders
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d81d9aec3d4b4606a4380fcc57816cd2
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Inability to switch from ARID1A-BAF to ARID1B-BAF impairs exit from pluripotency and commitment towards neural crest formation in ARID1B-related neurodevelopmental disorders

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