Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

Heba Radi AttaAllah, Asmaa Anwar Mohamed Mohamed, Mohamed A Hamid Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptCorrespondence: Mohamed A HamidDepartment of Ophthalmology,Faculty of Medicine, Minia University Hospital, Minia 61111, EgyptEmail drmohamedhamid83@mu.edu...

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Autores principales:	AttaAllah HR, Mohamed AAM, Hamid MA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	• retinitis pigmentosa • oct angiography • macular microvasculature Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/d820c4c6c80c4379bb7c2d4b2409a429
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spelling	oai:doaj.org-article:d820c4c6c80c4379bb7c2d4b2409a4292021-12-02T12:08:07ZQuantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography1177-5483https://doaj.org/article/d820c4c6c80c4379bb7c2d4b2409a4292020-06-01T00:00:00Zhttps://www.dovepress.com/quantification-of-macular-microvascular-changes-in-retinitis-pigmentos-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Heba Radi AttaAllah, Asmaa Anwar Mohamed Mohamed, Mohamed A Hamid Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptCorrespondence: Mohamed A HamidDepartment of Ophthalmology,Faculty of Medicine, Minia University Hospital, Minia 61111, EgyptEmail drmohamedhamid83@mu.edu.egPurpose: To investigate macular structural and microvascular changes in retinitis pigmentosa (RP) eyes compared to age-matched controls using spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA).Methods: This was a cross-sectional study. The foveal and parafoveal thickness and extent of ellipsoid zone (EZ) disruption were measured on OCT. The foveal avascular zone (FAZ) area and retinal vessel density (VD) were automatically calculated for superficial (SCP) and deep capillary plexuses (DCP) and choriocapillaris using OCTA-integrated software. VD was assessed for the whole 6 × 6 mm image, foveal and parafoveal regions. Quantitative measures were compared between healthy and diseased eyes.Results: The study included 30 eyes of 30 RP patients and 24 eyes of 24 controls. Mean age was 26.9± 6.4 years for RP patients and 27.4± 4.9 years for controls (p=0.76). Mean LogMAR visual acuity (VA) was 0.9± 0.5 for RP patients and 0.05± 0.05 for controls (p < 0.001). Foveal and parafoveal thicknesses were significantly lower in RP cases as compared to the control group. EZ disruption was observed in RP cases only (869± 211 μm). Mean FAZ area was significantly larger in RP eyes in both SCP and DCP. VD was significantly reduced in RP eyes at the level of SCP, DCP and choriocapillaris. VA, deep parafoveal VD, foveal, parafoveal and whole image choriocapillaris VD were negatively correlated with the extent of EZ disruption.Conclusion: We report OCTA findings in a relatively young cohort of RP patients. We demonstrated a reduction of retinal microvascular density in all studied layers on OCTA. We believe studying retinal vasculature in these patients is important, as a healthy blood supply is a prerequisite for the success of new cell-based therapies under trial for RP.Keywords: retinitis pigmentosa, OCT angiography, macular microvasculatureAttaAllah HRMohamed AAMHamid MADove Medical Pressarticle• retinitis pigmentosa • oct angiography • macular microvasculatureOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 1705-1713 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	• retinitis pigmentosa • oct angiography • macular microvasculature Ophthalmology RE1-994
spellingShingle	• retinitis pigmentosa • oct angiography • macular microvasculature Ophthalmology RE1-994 AttaAllah HR Mohamed AAM Hamid MA Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
description	Heba Radi AttaAllah, Asmaa Anwar Mohamed Mohamed, Mohamed A Hamid Department of Ophthalmology, Faculty of Medicine, Minia University, Minia, EgyptCorrespondence: Mohamed A HamidDepartment of Ophthalmology,Faculty of Medicine, Minia University Hospital, Minia 61111, EgyptEmail drmohamedhamid83@mu.edu.egPurpose: To investigate macular structural and microvascular changes in retinitis pigmentosa (RP) eyes compared to age-matched controls using spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA).Methods: This was a cross-sectional study. The foveal and parafoveal thickness and extent of ellipsoid zone (EZ) disruption were measured on OCT. The foveal avascular zone (FAZ) area and retinal vessel density (VD) were automatically calculated for superficial (SCP) and deep capillary plexuses (DCP) and choriocapillaris using OCTA-integrated software. VD was assessed for the whole 6 × 6 mm image, foveal and parafoveal regions. Quantitative measures were compared between healthy and diseased eyes.Results: The study included 30 eyes of 30 RP patients and 24 eyes of 24 controls. Mean age was 26.9± 6.4 years for RP patients and 27.4± 4.9 years for controls (p=0.76). Mean LogMAR visual acuity (VA) was 0.9± 0.5 for RP patients and 0.05± 0.05 for controls (p < 0.001). Foveal and parafoveal thicknesses were significantly lower in RP cases as compared to the control group. EZ disruption was observed in RP cases only (869± 211 μm). Mean FAZ area was significantly larger in RP eyes in both SCP and DCP. VD was significantly reduced in RP eyes at the level of SCP, DCP and choriocapillaris. VA, deep parafoveal VD, foveal, parafoveal and whole image choriocapillaris VD were negatively correlated with the extent of EZ disruption.Conclusion: We report OCTA findings in a relatively young cohort of RP patients. We demonstrated a reduction of retinal microvascular density in all studied layers on OCTA. We believe studying retinal vasculature in these patients is important, as a healthy blood supply is a prerequisite for the success of new cell-based therapies under trial for RP.Keywords: retinitis pigmentosa, OCT angiography, macular microvasculature
format	article
author	AttaAllah HR Mohamed AAM Hamid MA
author_facet	AttaAllah HR Mohamed AAM Hamid MA
author_sort	AttaAllah HR
title	Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
title_short	Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
title_full	Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
title_fullStr	Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
title_full_unstemmed	Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography
title_sort	quantification of macular microvascular changes in retinitis pigmentosa using optical coherence tomography angiography
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/d820c4c6c80c4379bb7c2d4b2409a429
work_keys_str_mv	AT attaallahhr quantificationofmacularmicrovascularchangesinretinitispigmentosausingopticalcoherencetomographyangiography AT mohamedaam quantificationofmacularmicrovascularchangesinretinitispigmentosausingopticalcoherencetomographyangiography AT hamidma quantificationofmacularmicrovascularchangesinretinitispigmentosausingopticalcoherencetomographyangiography
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Quantification of Macular Microvascular Changes in Retinitis Pigmentosa Using Optical Coherence Tomography Angiography

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