Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease

Abstract To explore the feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease and to compare it to strain measurements derived from transthoracic echocardiography (TTE). 43 consecutive patients with advanced cardiac valve disease and clinically indic...

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Autores principales:	Marius Vach, Johanna Vogelhuber, Marcel Weber, Alois M. Sprinkart, Claus C. Pieper, Wolfgang Block, Daniel Kuetting, Ulrike I. Attenberger, Julian A. Luetkens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8214d365c4d4269826d2b4bf841b12c
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spelling	oai:doaj.org-article:d8214d365c4d4269826d2b4bf841b12c2021-12-02T13:39:47ZFeasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease10.1038/s41598-021-88294-52045-2322https://doaj.org/article/d8214d365c4d4269826d2b4bf841b12c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88294-5https://doaj.org/toc/2045-2322Abstract To explore the feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease and to compare it to strain measurements derived from transthoracic echocardiography (TTE). 43 consecutive patients with advanced cardiac valve disease and clinically indicated retrospectively gated cardiac CTs were retrospectively analyzed. The longitudinal, circumferential as well as radial systolic strain were determined in all patients utilizing a commercially available CT strain software. In 36/43 (84%) patients, CT-derived longitudinal strain was compared to speckle-tracking TTE. Pearson’s correlation coefficients as well as Bland–Altman analysis were used to compare the CT-derived strain measurements to TTE. The intra- and inter-reader-reliability of the CT-derived strain measurements were assessed by intra-class correlation coefficients (ICCs). Strain measurements were feasible in all patients. CT-derived global longitudinal strain (GLS) correlated moderately with TTE-derived GLS (r = 0.6, p < 0.001). A moderate correlation between CT-derived GLS and CT-derived left ventricular ejection fraction was found (LVEF, r = − 0.66, p = 0.036). Bland–Altman analysis showed a systematic underestimation of myocardial strain by cardiac CT compared to TTE (mean difference: − 5.8%, 95% limit of agreement between − 13.3 and 1.8%). Strain measurements showed an excellent intra- and inter-reader-reliability with an intra-reader ICC of 1.0 and an inter-reader ICC of 0.99 for GLS measurements. CT-derived myocardial strain measurements are feasible in patients with advanced cardiac valve disease. They are highly reproducible and correlate with established parameters of strain measurements. Our results encourage the implementation of CT-derived strain measurement into clinical routine.Marius VachJohanna VogelhuberMarcel WeberAlois M. SprinkartClaus C. PieperWolfgang BlockDaniel KuettingUlrike I. AttenbergerJulian A. LuetkensNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marius Vach Johanna Vogelhuber Marcel Weber Alois M. Sprinkart Claus C. Pieper Wolfgang Block Daniel Kuetting Ulrike I. Attenberger Julian A. Luetkens Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease
description	Abstract To explore the feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease and to compare it to strain measurements derived from transthoracic echocardiography (TTE). 43 consecutive patients with advanced cardiac valve disease and clinically indicated retrospectively gated cardiac CTs were retrospectively analyzed. The longitudinal, circumferential as well as radial systolic strain were determined in all patients utilizing a commercially available CT strain software. In 36/43 (84%) patients, CT-derived longitudinal strain was compared to speckle-tracking TTE. Pearson’s correlation coefficients as well as Bland–Altman analysis were used to compare the CT-derived strain measurements to TTE. The intra- and inter-reader-reliability of the CT-derived strain measurements were assessed by intra-class correlation coefficients (ICCs). Strain measurements were feasible in all patients. CT-derived global longitudinal strain (GLS) correlated moderately with TTE-derived GLS (r = 0.6, p < 0.001). A moderate correlation between CT-derived GLS and CT-derived left ventricular ejection fraction was found (LVEF, r = − 0.66, p = 0.036). Bland–Altman analysis showed a systematic underestimation of myocardial strain by cardiac CT compared to TTE (mean difference: − 5.8%, 95% limit of agreement between − 13.3 and 1.8%). Strain measurements showed an excellent intra- and inter-reader-reliability with an intra-reader ICC of 1.0 and an inter-reader ICC of 0.99 for GLS measurements. CT-derived myocardial strain measurements are feasible in patients with advanced cardiac valve disease. They are highly reproducible and correlate with established parameters of strain measurements. Our results encourage the implementation of CT-derived strain measurement into clinical routine.
format	article
author	Marius Vach Johanna Vogelhuber Marcel Weber Alois M. Sprinkart Claus C. Pieper Wolfgang Block Daniel Kuetting Ulrike I. Attenberger Julian A. Luetkens
author_facet	Marius Vach Johanna Vogelhuber Marcel Weber Alois M. Sprinkart Claus C. Pieper Wolfgang Block Daniel Kuetting Ulrike I. Attenberger Julian A. Luetkens
author_sort	Marius Vach
title	Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease
title_short	Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease
title_full	Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease
title_fullStr	Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease
title_full_unstemmed	Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease
title_sort	feasibility of ct-derived myocardial strain measurement in patients with advanced cardiac valve disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8214d365c4d4269826d2b4bf841b12c
work_keys_str_mv	AT mariusvach feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT johannavogelhuber feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT marcelweber feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT aloismsprinkart feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT clauscpieper feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT wolfgangblock feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT danielkuetting feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT ulrikeiattenberger feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease AT julianaluetkens feasibilityofctderivedmyocardialstrainmeasurementinpatientswithadvancedcardiacvalvedisease
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Feasibility of CT-derived myocardial strain measurement in patients with advanced cardiac valve disease

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