STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.

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Autores principales:	Megumi Yamashita, Priscilla S.-W. Yeung, Christopher E. Ing, Beth A. McNally, Régis Pomès, Murali Prakriya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d822026f02ee422589e1d171ef62a857
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spelling	oai:doaj.org-article:d822026f02ee422589e1d171ef62a8572021-12-02T14:42:08ZSTIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate10.1038/ncomms145122041-1723https://doaj.org/article/d822026f02ee422589e1d171ef62a8572017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14512https://doaj.org/toc/2041-1723Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.Megumi YamashitaPriscilla S.-W. YeungChristopher E. IngBeth A. McNallyRégis PomèsMurali PrakriyaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Megumi Yamashita Priscilla S.-W. Yeung Christopher E. Ing Beth A. McNally Régis Pomès Murali Prakriya STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
description	Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.
format	article
author	Megumi Yamashita Priscilla S.-W. Yeung Christopher E. Ing Beth A. McNally Régis Pomès Murali Prakriya
author_facet	Megumi Yamashita Priscilla S.-W. Yeung Christopher E. Ing Beth A. McNally Régis Pomès Murali Prakriya
author_sort	Megumi Yamashita
title	STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_short	STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_full	STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_fullStr	STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_full_unstemmed	STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate
title_sort	stim1 activates crac channels through rotation of the pore helix to open a hydrophobic gate
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d822026f02ee422589e1d171ef62a857
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STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

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