STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

STIM1 activates CRAC channels through rotation of the pore helix to open a hydrophobic gate

Store-operated Ca2+channels (CRAC) are involved in several cellular functions. Here the authors identify a hydrophobic gate in the CRAC pore and show that CRAC activation by STIM1 involves rotation of the pore helix that hydrates this region to allow ion passage through the pore.

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Autores principales: Megumi Yamashita, Priscilla S.-W. Yeung, Christopher E. Ing, Beth A. McNally, Régis Pomès, Murali Prakriya
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
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Acceso en línea:https://doaj.org/article/d822026f02ee422589e1d171ef62a857
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