EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging

Ewing sarcoma (ES) is one of the most aggressive types of pediatric tumors. The lack of tools for the identification of ES has largely hindered clinical diagnosis and the improvement of treatment. To address this challenge, we synthesized a near‐infrared (NIR) fluorescent probe (CS2‐N‐E9R) that targ...

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Autores principales:	Yu Wang, Hengtang Mai, Ying Yuan, Hairen Chen, Song Wu, Xiang Hu, Aixi Yu
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Ewing sarcoma EWS–FLI1 near‐infrared imaging surgical guidance targeting peptide Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d8220428eb4940678605fe73579510f3
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spelling	oai:doaj.org-article:d8220428eb4940678605fe73579510f32021-12-02T10:31:06ZEWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging1878-02611574-789110.1002/1878-0261.13081https://doaj.org/article/d8220428eb4940678605fe73579510f32021-12-01T00:00:00Zhttps://doi.org/10.1002/1878-0261.13081https://doaj.org/toc/1574-7891https://doaj.org/toc/1878-0261Ewing sarcoma (ES) is one of the most aggressive types of pediatric tumors. The lack of tools for the identification of ES has largely hindered clinical diagnosis and the improvement of treatment. To address this challenge, we synthesized a near‐infrared (NIR) fluorescent probe (CS2‐N‐E9R) that targets the ES‐specific fusion protein EWS–FLI1 (E/F). This probe exhibited specific and high binding affinity to E/F. Further studies in animal models showed that CS2‐N‐E9R can be used to identify the boundaries of ES and lymph node metastases under a complex biological environment. These results demonstrate that CS2‐N‐E9R is a promising probe for early diagnosis and surgical guidance of ES through molecularly targeted NIR imaging.Yu WangHengtang MaiYing YuanHairen ChenSong WuXiang HuAixi YuWileyarticleEwing sarcomaEWS–FLI1near‐infrared imagingsurgical guidancetargeting peptideNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENMolecular Oncology, Vol 15, Iss 12, Pp 3706-3720 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ewing sarcoma EWS–FLI1 near‐infrared imaging surgical guidance targeting peptide Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Ewing sarcoma EWS–FLI1 near‐infrared imaging surgical guidance targeting peptide Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yu Wang Hengtang Mai Ying Yuan Hairen Chen Song Wu Xiang Hu Aixi Yu EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging
description	Ewing sarcoma (ES) is one of the most aggressive types of pediatric tumors. The lack of tools for the identification of ES has largely hindered clinical diagnosis and the improvement of treatment. To address this challenge, we synthesized a near‐infrared (NIR) fluorescent probe (CS2‐N‐E9R) that targets the ES‐specific fusion protein EWS–FLI1 (E/F). This probe exhibited specific and high binding affinity to E/F. Further studies in animal models showed that CS2‐N‐E9R can be used to identify the boundaries of ES and lymph node metastases under a complex biological environment. These results demonstrate that CS2‐N‐E9R is a promising probe for early diagnosis and surgical guidance of ES through molecularly targeted NIR imaging.
format	article
author	Yu Wang Hengtang Mai Ying Yuan Hairen Chen Song Wu Xiang Hu Aixi Yu
author_facet	Yu Wang Hengtang Mai Ying Yuan Hairen Chen Song Wu Xiang Hu Aixi Yu
author_sort	Yu Wang
title	EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging
title_short	EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging
title_full	EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging
title_fullStr	EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging
title_full_unstemmed	EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging
title_sort	ews–fli1‐targeting peptide identifies ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/d8220428eb4940678605fe73579510f3
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EWS–FLI1‐targeting peptide identifies Ewing sarcoma tumor boundaries and lymph node metastasis via near‐infrared imaging

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