Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique

Objective: To evaluate the clinical safety and efficacy of the retrograde perfusion technique in kidney transplantation. Methods: Between January 2001 and June 2011, 24 cases of kidney transplantation with kidneys perfused using the retrograde perfusion technique due to renal artery variations or in...

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Autores principales:	Xiu-Wu Han, Xiao-Dong Zhang, Yong Wang, Xi-Quan Tian, Jian-Wen Wang, Bu-He Amin, Wei Yan
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d822435166244e839c46b0aec0b11e8a
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spelling	oai:doaj.org-article:d822435166244e839c46b0aec0b11e8a2021-12-02T13:36:24ZShort- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique2095-882X10.1016/j.cdtm.2015.08.005https://doaj.org/article/d822435166244e839c46b0aec0b11e8a2015-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X15000511https://doaj.org/toc/2095-882XObjective: To evaluate the clinical safety and efficacy of the retrograde perfusion technique in kidney transplantation. Methods: Between January 2001 and June 2011, 24 cases of kidney transplantation with kidneys perfused using the retrograde perfusion technique due to renal artery variations or injury were selected as the observation group (retrograde perfussion group, RP group). Twenty-two cases of kidney transplantation via conventional perfusion were chosen as the control group (antegrade perfussion group, AP group). There were no statistically significant differences in donor data between the two groups. Cold ischemia time, warm ischemia time, renal perfusion time, amount of perfusion fluid, acute renal tubular necrosis, wound infection, urinary fistula, graft kidney function, and the 1-year, 3-year, and 5-year survival rates for the grafted kidney in both groups were observed and recorded. Results: The kidney perfusion time was shorter in the RP group than that in the AP group (3.14 Â± 1.00 vs. 5.02 Â± 1.15 min, P = 0.030). There were 10 cases of acute renal tubule necrosis in the RP group and 5 in the AP group. The length of hospital stay was 40Â Â±Â 14Â d in the RP group and 25Â Â±Â 12Â d in the AP group. The follow-up time was 3.5â8.5 years (mean 6.25Â years). The 1-, 3-, and 5-year survival rates for the grafted kidney were 95.8%, 75.5%, and 65.5% in the RP group and 97.1%, 82.5%, and 68.4% in the AP group, respectively (P>0.05). Conclusions: This study indicates that retrograde perfusion is safe and practicable for cadaveric kidney harvesting and can be regarded as a better alternative or remedial measure for a poorly perfused kidney due to vascular deformity or injury. Keywords: Retrograde perfusion, Allograft vascular deformity, Allograft vascular injury, Kidney procurementXiu-Wu HanXiao-Dong ZhangYong WangXi-Quan TianJian-Wen WangBu-He AminWei YanKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 1, Iss 3, Pp 163-168 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Xiu-Wu Han Xiao-Dong Zhang Yong Wang Xi-Quan Tian Jian-Wen Wang Bu-He Amin Wei Yan Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique
description	Objective: To evaluate the clinical safety and efficacy of the retrograde perfusion technique in kidney transplantation. Methods: Between January 2001 and June 2011, 24 cases of kidney transplantation with kidneys perfused using the retrograde perfusion technique due to renal artery variations or injury were selected as the observation group (retrograde perfussion group, RP group). Twenty-two cases of kidney transplantation via conventional perfusion were chosen as the control group (antegrade perfussion group, AP group). There were no statistically significant differences in donor data between the two groups. Cold ischemia time, warm ischemia time, renal perfusion time, amount of perfusion fluid, acute renal tubular necrosis, wound infection, urinary fistula, graft kidney function, and the 1-year, 3-year, and 5-year survival rates for the grafted kidney in both groups were observed and recorded. Results: The kidney perfusion time was shorter in the RP group than that in the AP group (3.14 Â± 1.00 vs. 5.02 Â± 1.15 min, P = 0.030). There were 10 cases of acute renal tubule necrosis in the RP group and 5 in the AP group. The length of hospital stay was 40Â Â±Â 14Â d in the RP group and 25Â Â±Â 12Â d in the AP group. The follow-up time was 3.5â8.5 years (mean 6.25Â years). The 1-, 3-, and 5-year survival rates for the grafted kidney were 95.8%, 75.5%, and 65.5% in the RP group and 97.1%, 82.5%, and 68.4% in the AP group, respectively (P>0.05). Conclusions: This study indicates that retrograde perfusion is safe and practicable for cadaveric kidney harvesting and can be regarded as a better alternative or remedial measure for a poorly perfused kidney due to vascular deformity or injury. Keywords: Retrograde perfusion, Allograft vascular deformity, Allograft vascular injury, Kidney procurement
format	article
author	Xiu-Wu Han Xiao-Dong Zhang Yong Wang Xi-Quan Tian Jian-Wen Wang Bu-He Amin Wei Yan
author_facet	Xiu-Wu Han Xiao-Dong Zhang Yong Wang Xi-Quan Tian Jian-Wen Wang Bu-He Amin Wei Yan
author_sort	Xiu-Wu Han
title	Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique
title_short	Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique
title_full	Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique
title_fullStr	Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique
title_full_unstemmed	Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique
title_sort	short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique
publisher	KeAi Communications Co., Ltd.
publishDate	2015
url	https://doaj.org/article/d822435166244e839c46b0aec0b11e8a
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Short- and long-term outcomes of kidney transplants with kidneys lavaged by retrograde perfusion technique

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