Fluctuating selection models and McDonald-Kreitman type analyses.

It is likely that the strength of selection acting upon a mutation varies through time due to changes in the environment. However, most population genetic theory assumes that the strength of selection remains constant. Here we investigate the consequences of fluctuating selection pressures on the qu...

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Autores principales:	Toni I Gossmann, David Waxman, Adam Eyre-Walker
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d822461b6ce744c5b20630850b854b6b
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spelling	oai:doaj.org-article:d822461b6ce744c5b20630850b854b6b2021-11-18T08:38:45ZFluctuating selection models and McDonald-Kreitman type analyses.1932-620310.1371/journal.pone.0084540https://doaj.org/article/d822461b6ce744c5b20630850b854b6b2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24409303/?tool=EBIhttps://doaj.org/toc/1932-6203It is likely that the strength of selection acting upon a mutation varies through time due to changes in the environment. However, most population genetic theory assumes that the strength of selection remains constant. Here we investigate the consequences of fluctuating selection pressures on the quantification of adaptive evolution using McDonald-Kreitman (MK) style approaches. In agreement with previous work, we show that fluctuating selection can generate evidence of adaptive evolution even when the expected strength of selection on a mutation is zero. However, we also find that the mutations, which contribute to both polymorphism and divergence tend, on average, to be positively selected during their lifetime, under fluctuating selection models. This is because mutations that fluctuate, by chance, to positive selected values, tend to reach higher frequencies in the population than those that fluctuate towards negative values. Hence the evidence of positive adaptive evolution detected under a fluctuating selection model by MK type approaches is genuine since fixed mutations tend to be advantageous on average during their lifetime. Never-the-less we show that methods tend to underestimate the rate of adaptive evolution when selection fluctuates.Toni I GossmannDavid WaxmanAdam Eyre-WalkerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e84540 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Toni I Gossmann David Waxman Adam Eyre-Walker Fluctuating selection models and McDonald-Kreitman type analyses.
description	It is likely that the strength of selection acting upon a mutation varies through time due to changes in the environment. However, most population genetic theory assumes that the strength of selection remains constant. Here we investigate the consequences of fluctuating selection pressures on the quantification of adaptive evolution using McDonald-Kreitman (MK) style approaches. In agreement with previous work, we show that fluctuating selection can generate evidence of adaptive evolution even when the expected strength of selection on a mutation is zero. However, we also find that the mutations, which contribute to both polymorphism and divergence tend, on average, to be positively selected during their lifetime, under fluctuating selection models. This is because mutations that fluctuate, by chance, to positive selected values, tend to reach higher frequencies in the population than those that fluctuate towards negative values. Hence the evidence of positive adaptive evolution detected under a fluctuating selection model by MK type approaches is genuine since fixed mutations tend to be advantageous on average during their lifetime. Never-the-less we show that methods tend to underestimate the rate of adaptive evolution when selection fluctuates.
format	article
author	Toni I Gossmann David Waxman Adam Eyre-Walker
author_facet	Toni I Gossmann David Waxman Adam Eyre-Walker
author_sort	Toni I Gossmann
title	Fluctuating selection models and McDonald-Kreitman type analyses.
title_short	Fluctuating selection models and McDonald-Kreitman type analyses.
title_full	Fluctuating selection models and McDonald-Kreitman type analyses.
title_fullStr	Fluctuating selection models and McDonald-Kreitman type analyses.
title_full_unstemmed	Fluctuating selection models and McDonald-Kreitman type analyses.
title_sort	fluctuating selection models and mcdonald-kreitman type analyses.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d822461b6ce744c5b20630850b854b6b
work_keys_str_mv	AT toniigossmann fluctuatingselectionmodelsandmcdonaldkreitmantypeanalyses AT davidwaxman fluctuatingselectionmodelsandmcdonaldkreitmantypeanalyses AT adameyrewalker fluctuatingselectionmodelsandmcdonaldkreitmantypeanalyses
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Fluctuating selection models and McDonald-Kreitman type analyses.

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