siRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in <named-content content-type="genus-species">Toxoplasma gondii</named-content>-Infected Cells

siRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in <named-content content-type="genus-species">Toxoplasma gondii</named-content>-Infected Cells

ABSTRACT Although it is established that oxygen availability regulates cellular metabolism and growth, little is known regarding how intracellular pathogens use host factors to grow at physiological oxygen levels. Therefore, large-scale human small interfering RNA screening was performed to identify...

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Autores principales: Matthew T. Menendez, Crystal Teygong, Kristin Wade, Celia Florimond, Ira J. Blader
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2015
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/d82378d4294242538f637a715e6ea518
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