Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

Abstract This work aimed to investigate the effect of different shim techniques, voxel sizes, and repetition time (TR) on using theT2 and T2* sequences to determine their optimum settings to investigate the quantification of iron in transfused dependent sickle cell patients. The effect of each of th...

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Autores principales:	Azza Ahmed, Amani Baldo, A. Sulieman, Hind Mirghani, Fouad A. Abolaban, I. I. Suliman, Isam Salih
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d8249cc277474e8ea0ad63c55d14c7a6
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spelling	oai:doaj.org-article:d8249cc277474e8ea0ad63c55d14c7a62021-12-02T13:44:14ZOptimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients10.1038/s41598-021-88116-82045-2322https://doaj.org/article/d8249cc277474e8ea0ad63c55d14c7a62021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88116-8https://doaj.org/toc/2045-2322Abstract This work aimed to investigate the effect of different shim techniques, voxel sizes, and repetition time (TR) on using theT2 and T2* sequences to determine their optimum settings to investigate the quantification of iron in transfused dependent sickle cell patients. The effect of each of these parameters was investigated on phantoms of different Gadolinium (Gd) concentrations, on 10 volunteers and 25 patients using a1 5T MRI Philips scanner. No significant difference between the three shim techniques was noticed in either T2 or T2* sequence measurements. Pixel sizes of 1 × 1 and 2 × 2 mm provided optimum results for T2 measurements. At 1 × 1 mm pixel size the T2* measurements experienced less error in measurements than the size of 2.5 × 2.5 mm used in the literature. Even though the slice thickness variation did not provide any changes in T2 measurements, the 12 mm provided optimum T2* measurements. TR variation did not yield significant changes on either T2 or T2* measurements. These results indicate that both T2 and T2* sequences can be further improved by providing more reliable measurements and reducing acquisition time.Azza AhmedAmani BaldoA. SuliemanHind MirghaniFouad A. AbolabanI. I. SulimanIsam SalihNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Azza Ahmed Amani Baldo A. Sulieman Hind Mirghani Fouad A. Abolaban I. I. Suliman Isam Salih Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients
description	Abstract This work aimed to investigate the effect of different shim techniques, voxel sizes, and repetition time (TR) on using theT2 and T2* sequences to determine their optimum settings to investigate the quantification of iron in transfused dependent sickle cell patients. The effect of each of these parameters was investigated on phantoms of different Gadolinium (Gd) concentrations, on 10 volunteers and 25 patients using a1 5T MRI Philips scanner. No significant difference between the three shim techniques was noticed in either T2 or T2* sequence measurements. Pixel sizes of 1 × 1 and 2 × 2 mm provided optimum results for T2 measurements. At 1 × 1 mm pixel size the T2* measurements experienced less error in measurements than the size of 2.5 × 2.5 mm used in the literature. Even though the slice thickness variation did not provide any changes in T2 measurements, the 12 mm provided optimum T2* measurements. TR variation did not yield significant changes on either T2 or T2* measurements. These results indicate that both T2 and T2* sequences can be further improved by providing more reliable measurements and reducing acquisition time.
format	article
author	Azza Ahmed Amani Baldo A. Sulieman Hind Mirghani Fouad A. Abolaban I. I. Suliman Isam Salih
author_facet	Azza Ahmed Amani Baldo A. Sulieman Hind Mirghani Fouad A. Abolaban I. I. Suliman Isam Salih
author_sort	Azza Ahmed
title	Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients
title_short	Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients
title_full	Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients
title_fullStr	Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients
title_full_unstemmed	Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients
title_sort	optimisation of t2 and t2* sequences in mri for better quantification of iron on transfused dependent sickle cell patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8249cc277474e8ea0ad63c55d14c7a6
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Optimisation of T2 and T2* sequences in MRI for better quantification of iron on transfused dependent sickle cell patients

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