Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption

Abstract Emergent evidence demonstrates that excessive consumption of high fat and high sugar (HFHS) diets has negative consequences on hippocampal and prefrontal cortex (PFC) function. Moreover, the delayed maturation of the PFC including the late development of parvalbumin-expressing (PV) interneu...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Amy C. Reichelt, Claire A. Lemieux, Oren Princz-Lebel, Ashmita Singh, Timothy J. Bussey, Lisa M. Saksida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d825032133824eaea89aa5923ee80632
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d825032133824eaea89aa5923ee80632
record_format	dspace
spelling	oai:doaj.org-article:d825032133824eaea89aa5923ee806322021-12-02T13:33:52ZAge-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption10.1038/s41598-021-85092-x2045-2322https://doaj.org/article/d825032133824eaea89aa5923ee806322021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85092-xhttps://doaj.org/toc/2045-2322Abstract Emergent evidence demonstrates that excessive consumption of high fat and high sugar (HFHS) diets has negative consequences on hippocampal and prefrontal cortex (PFC) function. Moreover, the delayed maturation of the PFC including the late development of parvalbumin-expressing (PV) interneurons and perineuronal nets (PNNs) may promote vulnerability to HFHS diet-induced nutritional stress. However, the young brain may have some resistance to diet-induced neuroinflammation. Thus, we examined the impact of a HFHS diet commencing either in adolescence or adulthood in male mice. PV interneurons, PNNs and microglia were assessed using immunohistochemistry. We observed greater numbers of PV neurons and PNNs in the hippocampus and the prelimbic and infralimbic PFC in adult mice in comparison to our younger cohort. Mice that consumed HFHS diet as adults had reduced numbers of hippocampal PV neurons and PNNs, which correlated with adiposity. However, we saw no effects of diet on PV and PNNs in the PFC. HFHS diet increased microgliosis in the adult cohort, and morphological changes to microglia were observed in the PFC and hippocampus of the adolescent cohort, with a shift to activated microglia phenotypes. Taken together, these findings demonstrate different regional and age-specific effects of obesogenic diets on PV neurons, PNNs and microglia.Amy C. ReicheltClaire A. LemieuxOren Princz-LebelAshmita SinghTimothy J. BusseyLisa M. SaksidaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amy C. Reichelt Claire A. Lemieux Oren Princz-Lebel Ashmita Singh Timothy J. Bussey Lisa M. Saksida Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption
description	Abstract Emergent evidence demonstrates that excessive consumption of high fat and high sugar (HFHS) diets has negative consequences on hippocampal and prefrontal cortex (PFC) function. Moreover, the delayed maturation of the PFC including the late development of parvalbumin-expressing (PV) interneurons and perineuronal nets (PNNs) may promote vulnerability to HFHS diet-induced nutritional stress. However, the young brain may have some resistance to diet-induced neuroinflammation. Thus, we examined the impact of a HFHS diet commencing either in adolescence or adulthood in male mice. PV interneurons, PNNs and microglia were assessed using immunohistochemistry. We observed greater numbers of PV neurons and PNNs in the hippocampus and the prelimbic and infralimbic PFC in adult mice in comparison to our younger cohort. Mice that consumed HFHS diet as adults had reduced numbers of hippocampal PV neurons and PNNs, which correlated with adiposity. However, we saw no effects of diet on PV and PNNs in the PFC. HFHS diet increased microgliosis in the adult cohort, and morphological changes to microglia were observed in the PFC and hippocampus of the adolescent cohort, with a shift to activated microglia phenotypes. Taken together, these findings demonstrate different regional and age-specific effects of obesogenic diets on PV neurons, PNNs and microglia.
format	article
author	Amy C. Reichelt Claire A. Lemieux Oren Princz-Lebel Ashmita Singh Timothy J. Bussey Lisa M. Saksida
author_facet	Amy C. Reichelt Claire A. Lemieux Oren Princz-Lebel Ashmita Singh Timothy J. Bussey Lisa M. Saksida
author_sort	Amy C. Reichelt
title	Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption
title_short	Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption
title_full	Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption
title_fullStr	Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption
title_full_unstemmed	Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption
title_sort	age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d825032133824eaea89aa5923ee80632
work_keys_str_mv	AT amycreichelt agedependentandregionspecificalterationofparvalbuminneuronsperineuronalnetsandmicrogliainthemouseprefrontalcortexandhippocampusfollowingobesogenicdietconsumption AT clairealemieux agedependentandregionspecificalterationofparvalbuminneuronsperineuronalnetsandmicrogliainthemouseprefrontalcortexandhippocampusfollowingobesogenicdietconsumption AT orenprinczlebel agedependentandregionspecificalterationofparvalbuminneuronsperineuronalnetsandmicrogliainthemouseprefrontalcortexandhippocampusfollowingobesogenicdietconsumption AT ashmitasingh agedependentandregionspecificalterationofparvalbuminneuronsperineuronalnetsandmicrogliainthemouseprefrontalcortexandhippocampusfollowingobesogenicdietconsumption AT timothyjbussey agedependentandregionspecificalterationofparvalbuminneuronsperineuronalnetsandmicrogliainthemouseprefrontalcortexandhippocampusfollowingobesogenicdietconsumption AT lisamsaksida agedependentandregionspecificalterationofparvalbuminneuronsperineuronalnetsandmicrogliainthemouseprefrontalcortexandhippocampusfollowingobesogenicdietconsumption
_version_	1718392824681988096

Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption

Ejemplares similares