Real-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach
Purpose: Triple-negative breast cancer (TNBC) is well known for its aggressive course and poor prognosis. In this study, we sought to investigate clinical, demographic, and pathologic characteristics and treatment outcomes of patients with refractory, metastatic TNBC selected by a clinical data ware...
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MDPI AG
2021
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oai:doaj.org-article:d828e4c6b0b945f582face840a2356072021-11-25T17:04:35ZReal-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach10.3390/cancers132258352072-6694https://doaj.org/article/d828e4c6b0b945f582face840a2356072021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/22/5835https://doaj.org/toc/2072-6694Purpose: Triple-negative breast cancer (TNBC) is well known for its aggressive course and poor prognosis. In this study, we sought to investigate clinical, demographic, and pathologic characteristics and treatment outcomes of patients with refractory, metastatic TNBC selected by a clinical data warehouse (CDW) approach. Patients and methods: Data were extracted from the real-time breast cancer registry integrated into the Data Analytics and Research Window for Integrated Knowledge C (DARWIN-C), the CDW of Samsung Medical Center. Between January 1997 and December 2019, a TNBC cohort was searched for in the breast cancer registry, which includes records from more than 40,000 patients. Among them, cases of pathologically confirmed metastatic TNBC (mTNBC) were selected as the cohort group (<i>n</i> = 451). The extracted data from the registry via the CDW platform included clinical, pathological, laboratory, and chemotherapy information. Refractory TNBC was defined as confirmed distant metastasis within one year after adjuvant treatment. Results: This study comprised a total of 451 patients with mTNBC, including 69 patients with de novo mTNBC, 131 patients in the nonrefractory TNBC group with confirmed stage IV disease after one year of adjuvant treatment, and 251 patients with refractory mTNBC, whose disease recurred as stage IV within one year after completing adjuvant treatment. The refractory mTNBC cohort was composed of patients with disease that recurred at stage IV after surgery (refractory mTNBC after surgery) (<i>n</i> = 207) and patients in whom metastasis was confirmed during neoadjuvant chemotherapy (unresectable TNBC due to progression during neoadjuvant chemotherapy) (<i>n</i> = 44). Patients in the refractory mTNBC group were younger than those in the nonrefractory group (median age 46 vs. 51 years; <i>p</i> < 0.001). Considering the pathological findings, the refractory group had a greater proportion of cases with Ki-67 ≥ 3+ than did the nonrefractory group (71% vs. 47%; <i>p</i> = 0.004). During a median 8.4 years of follow-up, the overall survival was 24.8 months in the nonrefractory mTNBC group and 14.3 months in the refractory mTNBC group (<i>p</i> < 0.001), and the median progression-free survival periods were 6.2 months and 4.2 months, respectively (<i>p</i> < 0.001). The median disease-free survival period was 30.1 months in the nonrefractory mTNBC group and only 7.6 months in the refractory mTNBC group. Factors related to metastatic sites affecting overall survival were liver metastasis at diagnosis (<i>p</i> < 0.001) and leptomeningeal involvement (<i>p</i> = 0.001). Conclusions: We revealed that patients with refractory mTNBC had a much poorer prognosis among all mTNBC cases and described the characteristics of this patient group.Hana KimHyo Jung KimHongsik KimHye Ryeon KimHyunji JoJoohyun HongRyul KimJi-Yeon KimJin Seok AhnYoung-Hyuck ImSe Kyung LeeHaeyoung KimSoo-Yong ShinYeon Hee ParkMDPI AGarticlemetastatic breast cancertriple-negative breast cancerCDWNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5835, p 5835 (2021) |
| institution |
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| collection |
DOAJ |
| language |
EN |
| topic |
metastatic breast cancer triple-negative breast cancer CDW Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
metastatic breast cancer triple-negative breast cancer CDW Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hana Kim Hyo Jung Kim Hongsik Kim Hye Ryeon Kim Hyunji Jo Joohyun Hong Ryul Kim Ji-Yeon Kim Jin Seok Ahn Young-Hyuck Im Se Kyung Lee Haeyoung Kim Soo-Yong Shin Yeon Hee Park Real-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach |
| description |
Purpose: Triple-negative breast cancer (TNBC) is well known for its aggressive course and poor prognosis. In this study, we sought to investigate clinical, demographic, and pathologic characteristics and treatment outcomes of patients with refractory, metastatic TNBC selected by a clinical data warehouse (CDW) approach. Patients and methods: Data were extracted from the real-time breast cancer registry integrated into the Data Analytics and Research Window for Integrated Knowledge C (DARWIN-C), the CDW of Samsung Medical Center. Between January 1997 and December 2019, a TNBC cohort was searched for in the breast cancer registry, which includes records from more than 40,000 patients. Among them, cases of pathologically confirmed metastatic TNBC (mTNBC) were selected as the cohort group (<i>n</i> = 451). The extracted data from the registry via the CDW platform included clinical, pathological, laboratory, and chemotherapy information. Refractory TNBC was defined as confirmed distant metastasis within one year after adjuvant treatment. Results: This study comprised a total of 451 patients with mTNBC, including 69 patients with de novo mTNBC, 131 patients in the nonrefractory TNBC group with confirmed stage IV disease after one year of adjuvant treatment, and 251 patients with refractory mTNBC, whose disease recurred as stage IV within one year after completing adjuvant treatment. The refractory mTNBC cohort was composed of patients with disease that recurred at stage IV after surgery (refractory mTNBC after surgery) (<i>n</i> = 207) and patients in whom metastasis was confirmed during neoadjuvant chemotherapy (unresectable TNBC due to progression during neoadjuvant chemotherapy) (<i>n</i> = 44). Patients in the refractory mTNBC group were younger than those in the nonrefractory group (median age 46 vs. 51 years; <i>p</i> < 0.001). Considering the pathological findings, the refractory group had a greater proportion of cases with Ki-67 ≥ 3+ than did the nonrefractory group (71% vs. 47%; <i>p</i> = 0.004). During a median 8.4 years of follow-up, the overall survival was 24.8 months in the nonrefractory mTNBC group and 14.3 months in the refractory mTNBC group (<i>p</i> < 0.001), and the median progression-free survival periods were 6.2 months and 4.2 months, respectively (<i>p</i> < 0.001). The median disease-free survival period was 30.1 months in the nonrefractory mTNBC group and only 7.6 months in the refractory mTNBC group. Factors related to metastatic sites affecting overall survival were liver metastasis at diagnosis (<i>p</i> < 0.001) and leptomeningeal involvement (<i>p</i> = 0.001). Conclusions: We revealed that patients with refractory mTNBC had a much poorer prognosis among all mTNBC cases and described the characteristics of this patient group. |
| format |
article |
| author |
Hana Kim Hyo Jung Kim Hongsik Kim Hye Ryeon Kim Hyunji Jo Joohyun Hong Ryul Kim Ji-Yeon Kim Jin Seok Ahn Young-Hyuck Im Se Kyung Lee Haeyoung Kim Soo-Yong Shin Yeon Hee Park |
| author_facet |
Hana Kim Hyo Jung Kim Hongsik Kim Hye Ryeon Kim Hyunji Jo Joohyun Hong Ryul Kim Ji-Yeon Kim Jin Seok Ahn Young-Hyuck Im Se Kyung Lee Haeyoung Kim Soo-Yong Shin Yeon Hee Park |
| author_sort |
Hana Kim |
| title |
Real-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach |
| title_short |
Real-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach |
| title_full |
Real-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach |
| title_fullStr |
Real-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach |
| title_full_unstemmed |
Real-World Data from a Refractory Triple-Negative Breast Cancer Cohort Selected Using a Clinical Data Warehouse Approach |
| title_sort |
real-world data from a refractory triple-negative breast cancer cohort selected using a clinical data warehouse approach |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/d828e4c6b0b945f582face840a235607 |
| work_keys_str_mv |
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