Mechanisms of neuroprotective action of incretin mimetics

Recently, on the pharmacological market, new drugs from the class of incretin mimetics, or glucagon-like peptide-1 (GLP-1) receptor agonists, which have proven their high effectiveness in type 2 diabetes mellitus therapy, have appeared. At present, much attention has been paid to the pleotropic effe...

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Autores principales:	Timur Dmitrievich Vlasov, Anna Vladimirovna Simanenkova, Svetlana Vladimirovna Dora, Evgeniy Vladimirovich Shlyakhto
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2016
Materias:	type 2 diabetes mellitus incretinomimetics glucagon-like peptide-1 receptor agonists neuroprotection ischemic stroke neurodegenerative diseases Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/d82c6f552639423ca0f5daca24988975
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spelling	oai:doaj.org-article:d82c6f552639423ca0f5daca249889752021-11-14T09:00:20ZMechanisms of neuroprotective action of incretin mimetics2072-03512072-037810.14341/DM7192https://doaj.org/article/d82c6f552639423ca0f5daca249889752016-01-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/7192https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Recently, on the pharmacological market, new drugs from the class of incretin mimetics, or glucagon-like peptide-1 (GLP-1) receptor agonists, which have proven their high effectiveness in type 2 diabetes mellitus therapy, have appeared. At present, much attention has been paid to the pleotropic effects of incretin mimetics. In a number of both experimental and clinical studies, cardioprotective effects of this medication group have been demonstrated. The present review elucidates existing data about neuroprotective effects of GLP-1 receptor agonists in brain ischaemia and in nonischaemic nervous system diseases such as diabetic neuropathy and neurodegenerative disorders. The possible mechanisms for these effects, which appear to be primarily antioxidant effects, anti-inflammatory effects, antiapoptotic effects and an increase in neurons differentiation, are discussed.Timur Dmitrievich VlasovAnna Vladimirovna SimanenkovaSvetlana Vladimirovna DoraEvgeniy Vladimirovich ShlyakhtoEndocrinology Research Centrearticletype 2 diabetes mellitusincretinomimeticsglucagon-like peptide-1 receptor agonistsneuroprotectionischemic strokeneurodegenerative diseasesNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 19, Iss 1, Pp 16-23 (2016)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus incretinomimetics glucagon-like peptide-1 receptor agonists neuroprotection ischemic stroke neurodegenerative diseases Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus incretinomimetics glucagon-like peptide-1 receptor agonists neuroprotection ischemic stroke neurodegenerative diseases Nutritional diseases. Deficiency diseases RC620-627 Timur Dmitrievich Vlasov Anna Vladimirovna Simanenkova Svetlana Vladimirovna Dora Evgeniy Vladimirovich Shlyakhto Mechanisms of neuroprotective action of incretin mimetics
description	Recently, on the pharmacological market, new drugs from the class of incretin mimetics, or glucagon-like peptide-1 (GLP-1) receptor agonists, which have proven their high effectiveness in type 2 diabetes mellitus therapy, have appeared. At present, much attention has been paid to the pleotropic effects of incretin mimetics. In a number of both experimental and clinical studies, cardioprotective effects of this medication group have been demonstrated. The present review elucidates existing data about neuroprotective effects of GLP-1 receptor agonists in brain ischaemia and in nonischaemic nervous system diseases such as diabetic neuropathy and neurodegenerative disorders. The possible mechanisms for these effects, which appear to be primarily antioxidant effects, anti-inflammatory effects, antiapoptotic effects and an increase in neurons differentiation, are discussed.
format	article
author	Timur Dmitrievich Vlasov Anna Vladimirovna Simanenkova Svetlana Vladimirovna Dora Evgeniy Vladimirovich Shlyakhto
author_facet	Timur Dmitrievich Vlasov Anna Vladimirovna Simanenkova Svetlana Vladimirovna Dora Evgeniy Vladimirovich Shlyakhto
author_sort	Timur Dmitrievich Vlasov
title	Mechanisms of neuroprotective action of incretin mimetics
title_short	Mechanisms of neuroprotective action of incretin mimetics
title_full	Mechanisms of neuroprotective action of incretin mimetics
title_fullStr	Mechanisms of neuroprotective action of incretin mimetics
title_full_unstemmed	Mechanisms of neuroprotective action of incretin mimetics
title_sort	mechanisms of neuroprotective action of incretin mimetics
publisher	Endocrinology Research Centre
publishDate	2016
url	https://doaj.org/article/d82c6f552639423ca0f5daca24988975
work_keys_str_mv	AT timurdmitrievichvlasov mechanismsofneuroprotectiveactionofincretinmimetics AT annavladimirovnasimanenkova mechanismsofneuroprotectiveactionofincretinmimetics AT svetlanavladimirovnadora mechanismsofneuroprotectiveactionofincretinmimetics AT evgeniyvladimirovichshlyakhto mechanismsofneuroprotectiveactionofincretinmimetics
_version_	1718429558222356480

Mechanisms of neuroprotective action of incretin mimetics

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