STING suppresses bone cancer pain via immune and neuronal modulation

There is an unmet clinical need to develop therapies to alleviate metastatic bone pain, frequently observed in patients with advanced cancers. Here, using mouse models of bone cancer pain, the authors show that STING agonists not only suppress bone cancer tumor burden, but also attenuate bone pain a...

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Autores principales:	Kaiyuan Wang, Christopher R. Donnelly, Changyu Jiang, Yihan Liao, Xin Luo, Xueshu Tao, Sangsu Bang, Aidan McGinnis, Michael Lee, Matthew J. Hilton, Ru-Rong Ji
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d82ef968c2e84210ad88047195778682
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spelling	oai:doaj.org-article:d82ef968c2e84210ad880471957786822021-12-02T18:47:10ZSTING suppresses bone cancer pain via immune and neuronal modulation10.1038/s41467-021-24867-22041-1723https://doaj.org/article/d82ef968c2e84210ad880471957786822021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24867-2https://doaj.org/toc/2041-1723There is an unmet clinical need to develop therapies to alleviate metastatic bone pain, frequently observed in patients with advanced cancers. Here, using mouse models of bone cancer pain, the authors show that STING agonists not only suppress bone cancer tumor burden, but also attenuate bone pain and reduce cancer-induced bone destruction.Kaiyuan WangChristopher R. DonnellyChangyu JiangYihan LiaoXin LuoXueshu TaoSangsu BangAidan McGinnisMichael LeeMatthew J. HiltonRu-Rong JiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaiyuan Wang Christopher R. Donnelly Changyu Jiang Yihan Liao Xin Luo Xueshu Tao Sangsu Bang Aidan McGinnis Michael Lee Matthew J. Hilton Ru-Rong Ji STING suppresses bone cancer pain via immune and neuronal modulation
description	There is an unmet clinical need to develop therapies to alleviate metastatic bone pain, frequently observed in patients with advanced cancers. Here, using mouse models of bone cancer pain, the authors show that STING agonists not only suppress bone cancer tumor burden, but also attenuate bone pain and reduce cancer-induced bone destruction.
format	article
author	Kaiyuan Wang Christopher R. Donnelly Changyu Jiang Yihan Liao Xin Luo Xueshu Tao Sangsu Bang Aidan McGinnis Michael Lee Matthew J. Hilton Ru-Rong Ji
author_facet	Kaiyuan Wang Christopher R. Donnelly Changyu Jiang Yihan Liao Xin Luo Xueshu Tao Sangsu Bang Aidan McGinnis Michael Lee Matthew J. Hilton Ru-Rong Ji
author_sort	Kaiyuan Wang
title	STING suppresses bone cancer pain via immune and neuronal modulation
title_short	STING suppresses bone cancer pain via immune and neuronal modulation
title_full	STING suppresses bone cancer pain via immune and neuronal modulation
title_fullStr	STING suppresses bone cancer pain via immune and neuronal modulation
title_full_unstemmed	STING suppresses bone cancer pain via immune and neuronal modulation
title_sort	sting suppresses bone cancer pain via immune and neuronal modulation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d82ef968c2e84210ad88047195778682
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STING suppresses bone cancer pain via immune and neuronal modulation

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