Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols

Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the authors report an organocatalytic transisopropenylati...

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Autores principales:	Na Yu, Yang Xu, Tao Liu, Haiping Zhong, Zunkai Xu, Tianjiao Ji, Hui Zou, Jingqing Mu, Ziqi Chen, Xing-Jie Liang, Linqi Shi, Daniel S. Kohane, Shutao Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d8349ea0e4a54f0288059ddac35d6da1
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spelling	oai:doaj.org-article:d8349ea0e4a54f0288059ddac35d6da12021-12-02T18:48:11ZModular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols10.1038/s41467-021-25856-12041-1723https://doaj.org/article/d8349ea0e4a54f0288059ddac35d6da12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25856-1https://doaj.org/toc/2041-1723Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the authors report an organocatalytic transisopropenylation approach for IPPE synthesis in mild reaction conditions and with wide range of substrates, and use it to prepare acid-sensitive ketal-linked prodrugs and biomaterials.Na YuYang XuTao LiuHaiping ZhongZunkai XuTianjiao JiHui ZouJingqing MuZiqi ChenXing-Jie LiangLinqi ShiDaniel S. KohaneShutao GuoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Na Yu Yang Xu Tao Liu Haiping Zhong Zunkai Xu Tianjiao Ji Hui Zou Jingqing Mu Ziqi Chen Xing-Jie Liang Linqi Shi Daniel S. Kohane Shutao Guo Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols
description	Isopropenyl ethers (IPPEs) are essential intermediates for obtaining ketal-based prodrugs and biomaterials, but traditional approaches for their synthesis are limited by poor functional group compatibility and harsh reaction conditions. Here, the authors report an organocatalytic transisopropenylation approach for IPPE synthesis in mild reaction conditions and with wide range of substrates, and use it to prepare acid-sensitive ketal-linked prodrugs and biomaterials.
format	article
author	Na Yu Yang Xu Tao Liu Haiping Zhong Zunkai Xu Tianjiao Ji Hui Zou Jingqing Mu Ziqi Chen Xing-Jie Liang Linqi Shi Daniel S. Kohane Shutao Guo
author_facet	Na Yu Yang Xu Tao Liu Haiping Zhong Zunkai Xu Tianjiao Ji Hui Zou Jingqing Mu Ziqi Chen Xing-Jie Liang Linqi Shi Daniel S. Kohane Shutao Guo
author_sort	Na Yu
title	Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols
title_short	Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols
title_full	Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols
title_fullStr	Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols
title_full_unstemmed	Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols
title_sort	modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d8349ea0e4a54f0288059ddac35d6da1
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Modular ketal-linked prodrugs and biomaterials enabled by organocatalytic transisopropenylation of alcohols

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