Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target

Breast cancer is one of the cancers leading to most death cases among women and metastasis is the major cause of breast cancer mortality. In this study, Corylin, the flavonoid compound which is extracted and purified from Psoralea corylifolia L., the effect on breast cancer metastasis was investigat...

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Autores principales:	Shourong Liu, Li Wang, Run Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	corylin linc00963 mir-34c breast cancer metastasis Medicine R
Acceso en línea:	https://doaj.org/article/d83c9a4aab4f42e4b43905e13ca24e54
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spelling	oai:doaj.org-article:d83c9a4aab4f42e4b43905e13ca24e542021-11-26T11:19:48ZCorylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target1993-28201819-635710.1080/19932820.2021.1883224https://doaj.org/article/d83c9a4aab4f42e4b43905e13ca24e542021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19932820.2021.1883224https://doaj.org/toc/1993-2820https://doaj.org/toc/1819-6357Breast cancer is one of the cancers leading to most death cases among women and metastasis is the major cause of breast cancer mortality. In this study, Corylin, the flavonoid compound which is extracted and purified from Psoralea corylifolia L., the effect on breast cancer metastasis was investigated. Corylin showed inhibitory effect on migration and invasion abilities of breast cancer cells. Meanwhile, the epithelial–mesenchymal transition was also regulated by corylin. The long non-coding RNA LINC00963 was found to have a significantly high expression level in breast cancer while it can be down-regulated by corylin. In addition, both wound-healing assay and transwell assay showed that LINC00963 induced breast cancer cells metastasis. MiR-34c was increased by corylin treatment depending on p53, and it was firstly identified that the LINC00963 was a direct target of miR-34c. Corylin was verified here that it prohibited MCF-7 migration and invasion depending on miR-34c/LINC00963 target. In conclusion, corylin suppresses metastasis of breast cancer cells via increasing miR-34c expression, which was dependent on p53. LINC00963 was a direct target of miR-34c and the target axis was necessary for corylin function. Therefore, corylin is a promising drug candidate and LINC00963 can be seen as a promising target in breast cancer treatmentShourong LiuLi WangRun ZhangTaylor & Francis Grouparticlecorylinlinc00963mir-34cbreast cancermetastasisMedicineRENLibyan Journal of Medicine, Vol 16, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	corylin linc00963 mir-34c breast cancer metastasis Medicine R
spellingShingle	corylin linc00963 mir-34c breast cancer metastasis Medicine R Shourong Liu Li Wang Run Zhang Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target
description	Breast cancer is one of the cancers leading to most death cases among women and metastasis is the major cause of breast cancer mortality. In this study, Corylin, the flavonoid compound which is extracted and purified from Psoralea corylifolia L., the effect on breast cancer metastasis was investigated. Corylin showed inhibitory effect on migration and invasion abilities of breast cancer cells. Meanwhile, the epithelial–mesenchymal transition was also regulated by corylin. The long non-coding RNA LINC00963 was found to have a significantly high expression level in breast cancer while it can be down-regulated by corylin. In addition, both wound-healing assay and transwell assay showed that LINC00963 induced breast cancer cells metastasis. MiR-34c was increased by corylin treatment depending on p53, and it was firstly identified that the LINC00963 was a direct target of miR-34c. Corylin was verified here that it prohibited MCF-7 migration and invasion depending on miR-34c/LINC00963 target. In conclusion, corylin suppresses metastasis of breast cancer cells via increasing miR-34c expression, which was dependent on p53. LINC00963 was a direct target of miR-34c and the target axis was necessary for corylin function. Therefore, corylin is a promising drug candidate and LINC00963 can be seen as a promising target in breast cancer treatment
format	article
author	Shourong Liu Li Wang Run Zhang
author_facet	Shourong Liu Li Wang Run Zhang
author_sort	Shourong Liu
title	Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target
title_short	Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target
title_full	Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target
title_fullStr	Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target
title_full_unstemmed	Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target
title_sort	corylin suppresses metastasis of breast cancer cells by modulating mir-34c/linc00963 target
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/d83c9a4aab4f42e4b43905e13ca24e54
work_keys_str_mv	AT shourongliu corylinsuppressesmetastasisofbreastcancercellsbymodulatingmir34clinc00963target AT liwang corylinsuppressesmetastasisofbreastcancercellsbymodulatingmir34clinc00963target AT runzhang corylinsuppressesmetastasisofbreastcancercellsbymodulatingmir34clinc00963target
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Corylin suppresses metastasis of breast cancer cells by modulating miR-34c/LINC00963 target

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