Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves

Background: Curcumin has been used as an additive in the diet of animals in recent years due to the potent medicinal properties of this molecule. Objective: To evaluate whether the addition of curcumin to the diet of calves at different phases (pre- and post-weaning) has a positive effect on metabol...

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Autores principales:	Patrícia Glombowsky, Andreia Volpato, Gabriela Campigotto, Natan M. Soldá, Daiane da S. dos Santo, Nathieli B. Bottari, Maria Rosa C. Schetinger, Vera M. Morsch, Fernanda Rigon, Ana Luiza B. Schogor, Aleksandro S. Da Silva
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2020
Materias:	animal stress antioxidants calves cattle growth curcumin eimeria parasitology supplementation Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/d83fff640c974616aca011e2b31c12cb
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spelling	oai:doaj.org-article:d83fff640c974616aca011e2b31c12cb2021-12-01T15:44:01ZDietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves2256-295810.17533/udea.rccp.v33n1a02https://doaj.org/article/d83fff640c974616aca011e2b31c12cb2020-01-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/rccp/article/view/338066https://doaj.org/toc/2256-2958Background: Curcumin has been used as an additive in the diet of animals in recent years due to the potent medicinal properties of this molecule. Objective: To evaluate whether the addition of curcumin to the diet of calves at different phases (pre- and post-weaning) has a positive effect on metabolic profile, performance, and anti-coccidian action. Methods: Thirtythree Holstein calves were selected at various phases of development: Experiment 1 (E1: n=10) 18±7 (pre-weaning), Experiment 2 (E2: n=11) 64±4 (pre-weaning) and Experiment 3 (E3: n=12) 95±8 (post-weaning) days of life. The calves were separated in three groups according to their phase of development. In each experiment, animals were divided into two sub-groups: control and curcumin. The curcumin groups received 200 mg of additive per animal/day either in milk (pre-weaning) or concentrate (post-weaning). Fecal collections were performed on days 0, 10 and 15 of the experiment to count Eimeria oocysts per gram of feces and to perform fecal score analysis. Complete blood counts, oxidant and antioxidant profiles, protein metabolism markers, lipid levels, glucose levels, and animal weights were measured. Analyses of digestibility and composition of the diet used in Experiment 3 (post-weaning) were also performed. Results: Independent of phase, animals that received curcumin had greater weight gain on days 0 to 15 (E1, E2 and E3 p=0.04, 0.001 and 0.001, respectively), probably due to the increased digestibility of hay and concentrate at 72h (p=0.03 and 0.02, respectively). The supplemented calves had lower level of oxidants (thiobarbituric acid reactive substances –TBARS- and reactive oxygen species –ROS-), indicating that free radical levels in serum and lipid peroxidation were lower. This was probably due to increased enzymatic antioxidants gluthatione S-transferase (E1, E2 and E3 p=0.001, 0.001 and 0.02, respectively), catalase (E1 p=0.001) and superoxide dismutase (E3 p=0.001) in treated animals at day 15. Furthermore, calves receiving curcumin had lower numeric number of Eimeria infection during the experimental period, and the difference was significant in day 15 (E1 and E2 p=0.02, and 0.001, respectively). Conclusion: Curcumin supplementation to dairy calves has coccidiostatic potential, favoring weight gain.Patrícia GlombowskyAndreia VolpatoGabriela CampigottoNatan M. SoldáDaiane da S. dos SantoNathieli B. BottariMaria Rosa C. SchetingerVera M. MorschFernanda RigonAna Luiza B. SchogorAleksandro S. Da SilvaUniversidad de Antioquiaarticleanimal stressantioxidantscalvescattle growthcurcumineimeriaparasitologysupplementationAnimal cultureSF1-1100ENRevista Colombiana de Ciencias Pecuarias, Vol 33, Iss 1, Pp 16-31 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	animal stress antioxidants calves cattle growth curcumin eimeria parasitology supplementation Animal culture SF1-1100
spellingShingle	animal stress antioxidants calves cattle growth curcumin eimeria parasitology supplementation Animal culture SF1-1100 Patrícia Glombowsky Andreia Volpato Gabriela Campigotto Natan M. Soldá Daiane da S. dos Santo Nathieli B. Bottari Maria Rosa C. Schetinger Vera M. Morsch Fernanda Rigon Ana Luiza B. Schogor Aleksandro S. Da Silva Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
description	Background: Curcumin has been used as an additive in the diet of animals in recent years due to the potent medicinal properties of this molecule. Objective: To evaluate whether the addition of curcumin to the diet of calves at different phases (pre- and post-weaning) has a positive effect on metabolic profile, performance, and anti-coccidian action. Methods: Thirtythree Holstein calves were selected at various phases of development: Experiment 1 (E1: n=10) 18±7 (pre-weaning), Experiment 2 (E2: n=11) 64±4 (pre-weaning) and Experiment 3 (E3: n=12) 95±8 (post-weaning) days of life. The calves were separated in three groups according to their phase of development. In each experiment, animals were divided into two sub-groups: control and curcumin. The curcumin groups received 200 mg of additive per animal/day either in milk (pre-weaning) or concentrate (post-weaning). Fecal collections were performed on days 0, 10 and 15 of the experiment to count Eimeria oocysts per gram of feces and to perform fecal score analysis. Complete blood counts, oxidant and antioxidant profiles, protein metabolism markers, lipid levels, glucose levels, and animal weights were measured. Analyses of digestibility and composition of the diet used in Experiment 3 (post-weaning) were also performed. Results: Independent of phase, animals that received curcumin had greater weight gain on days 0 to 15 (E1, E2 and E3 p=0.04, 0.001 and 0.001, respectively), probably due to the increased digestibility of hay and concentrate at 72h (p=0.03 and 0.02, respectively). The supplemented calves had lower level of oxidants (thiobarbituric acid reactive substances –TBARS- and reactive oxygen species –ROS-), indicating that free radical levels in serum and lipid peroxidation were lower. This was probably due to increased enzymatic antioxidants gluthatione S-transferase (E1, E2 and E3 p=0.001, 0.001 and 0.02, respectively), catalase (E1 p=0.001) and superoxide dismutase (E3 p=0.001) in treated animals at day 15. Furthermore, calves receiving curcumin had lower numeric number of Eimeria infection during the experimental period, and the difference was significant in day 15 (E1 and E2 p=0.02, and 0.001, respectively). Conclusion: Curcumin supplementation to dairy calves has coccidiostatic potential, favoring weight gain.
format	article
author	Patrícia Glombowsky Andreia Volpato Gabriela Campigotto Natan M. Soldá Daiane da S. dos Santo Nathieli B. Bottari Maria Rosa C. Schetinger Vera M. Morsch Fernanda Rigon Ana Luiza B. Schogor Aleksandro S. Da Silva
author_facet	Patrícia Glombowsky Andreia Volpato Gabriela Campigotto Natan M. Soldá Daiane da S. dos Santo Nathieli B. Bottari Maria Rosa C. Schetinger Vera M. Morsch Fernanda Rigon Ana Luiza B. Schogor Aleksandro S. Da Silva
author_sort	Patrícia Glombowsky
title	Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
title_short	Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
title_full	Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
title_fullStr	Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
title_full_unstemmed	Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
title_sort	dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves
publisher	Universidad de Antioquia
publishDate	2020
url	https://doaj.org/article/d83fff640c974616aca011e2b31c12cb
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Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves

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