A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle

A highly conserved sequence of the viral TAP inhibitor ICP47 is required for freezing of the peptide transport cycle

Abstract The transporter associated with antigen processing (TAP) translocates antigenic peptides into the endoplasmic reticulum (ER) lumen for loading onto MHC class I molecules. This is a key step in the control of viral infections through CD8+ T-cells. The herpes simplex virus type-1 encodes an 8...

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Autores principales: Tony Matschulla, Richard Berry, Carolin Gerke, Marius Döring, Julia Busch, Jennifer Paijo, Ulrich Kalinke, Frank Momburg, Hartmut Hengel, Anne Halenius
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/d8467302d44249fdb0099d71445a063d
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