High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

It is unclear how intra-tumoral heterogeneity contributes to metastasis. Here the authors study the clonal dynamics of triple negative breast cancer metastasis using patient derived xenografts and demonstrate that primary tumor clones harbor properties that support seeding and colonization of multip...

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Autores principales:	Gloria V. Echeverria, Emily Powell, Sahil Seth, Zhongqi Ge, Alessandro Carugo, Christopher Bristow, Michael Peoples, Frederick Robinson, Huan Qiu, Jiansu Shao, Sabrina L. Jeter-Jones, Xiaomei Zhang, Vandhana Ramamoorthy, Shirong Cai, Wenhui Wu, Giulio Draetta, Stacy L. Moulder, William F. Symmans, Jeffrey T. Chang, Timothy P. Heffernan, Helen Piwnica-Worms
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d84938082d1647899042d8810ab7582c
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spelling	oai:doaj.org-article:d84938082d1647899042d8810ab7582c2021-12-02T14:41:28ZHigh-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer10.1038/s41467-018-07406-42041-1723https://doaj.org/article/d84938082d1647899042d8810ab7582c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07406-4https://doaj.org/toc/2041-1723It is unclear how intra-tumoral heterogeneity contributes to metastasis. Here the authors study the clonal dynamics of triple negative breast cancer metastasis using patient derived xenografts and demonstrate that primary tumor clones harbor properties that support seeding and colonization of multiple organs.Gloria V. EcheverriaEmily PowellSahil SethZhongqi GeAlessandro CarugoChristopher BristowMichael PeoplesFrederick RobinsonHuan QiuJiansu ShaoSabrina L. Jeter-JonesXiaomei ZhangVandhana RamamoorthyShirong CaiWenhui WuGiulio DraettaStacy L. MoulderWilliam F. SymmansJeffrey T. ChangTimothy P. HeffernanHelen Piwnica-WormsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gloria V. Echeverria Emily Powell Sahil Seth Zhongqi Ge Alessandro Carugo Christopher Bristow Michael Peoples Frederick Robinson Huan Qiu Jiansu Shao Sabrina L. Jeter-Jones Xiaomei Zhang Vandhana Ramamoorthy Shirong Cai Wenhui Wu Giulio Draetta Stacy L. Moulder William F. Symmans Jeffrey T. Chang Timothy P. Heffernan Helen Piwnica-Worms High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
description	It is unclear how intra-tumoral heterogeneity contributes to metastasis. Here the authors study the clonal dynamics of triple negative breast cancer metastasis using patient derived xenografts and demonstrate that primary tumor clones harbor properties that support seeding and colonization of multiple organs.
format	article
author	Gloria V. Echeverria Emily Powell Sahil Seth Zhongqi Ge Alessandro Carugo Christopher Bristow Michael Peoples Frederick Robinson Huan Qiu Jiansu Shao Sabrina L. Jeter-Jones Xiaomei Zhang Vandhana Ramamoorthy Shirong Cai Wenhui Wu Giulio Draetta Stacy L. Moulder William F. Symmans Jeffrey T. Chang Timothy P. Heffernan Helen Piwnica-Worms
author_facet	Gloria V. Echeverria Emily Powell Sahil Seth Zhongqi Ge Alessandro Carugo Christopher Bristow Michael Peoples Frederick Robinson Huan Qiu Jiansu Shao Sabrina L. Jeter-Jones Xiaomei Zhang Vandhana Ramamoorthy Shirong Cai Wenhui Wu Giulio Draetta Stacy L. Moulder William F. Symmans Jeffrey T. Chang Timothy P. Heffernan Helen Piwnica-Worms
author_sort	Gloria V. Echeverria
title	High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
title_short	High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
title_full	High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
title_fullStr	High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
title_full_unstemmed	High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
title_sort	high-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d84938082d1647899042d8810ab7582c
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High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer

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