Microbial dysbiosis is associated with human breast cancer.

Breast cancer affects one in eight women in their lifetime. Though diet, age and genetic predisposition are established risk factors, the majority of breast cancers have unknown etiology. The human microbiota refers to the collection of microbes inhabiting the human body. Imbalance in microbial comm...

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Autores principales:	Caiyun Xuan, Jaime M Shamonki, Alice Chung, Maggie L Dinome, Maureen Chung, Peter A Sieling, Delphine J Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d84ba8bffe4343799788665adccf17bd
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spelling	oai:doaj.org-article:d84ba8bffe4343799788665adccf17bd2021-11-18T08:38:17ZMicrobial dysbiosis is associated with human breast cancer.1932-620310.1371/journal.pone.0083744https://doaj.org/article/d84ba8bffe4343799788665adccf17bd2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24421902/?tool=EBIhttps://doaj.org/toc/1932-6203Breast cancer affects one in eight women in their lifetime. Though diet, age and genetic predisposition are established risk factors, the majority of breast cancers have unknown etiology. The human microbiota refers to the collection of microbes inhabiting the human body. Imbalance in microbial communities, or microbial dysbiosis, has been implicated in various human diseases including obesity, diabetes, and colon cancer. Therefore, we investigated the potential role of microbiota in breast cancer by next-generation sequencing using breast tumor tissue and paired normal adjacent tissue from the same patient. In a qualitative survey of the breast microbiota DNA, we found that the bacterium Methylobacterium radiotolerans is relatively enriched in tumor tissue, while the bacterium Sphingomonas yanoikuyae is relatively enriched in paired normal tissue. The relative abundances of these two bacterial species were inversely correlated in paired normal breast tissue but not in tumor tissue, indicating that dysbiosis is associated with breast cancer. Furthermore, the total bacterial DNA load was reduced in tumor versus paired normal and healthy breast tissue as determined by quantitative PCR. Interestingly, bacterial DNA load correlated inversely with advanced disease, a finding that could have broad implications in diagnosis and staging of breast cancer. Lastly, we observed lower basal levels of antibacterial response gene expression in tumor versus healthy breast tissue. Taken together, these data indicate that microbial DNA is present in the breast and that bacteria or their components may influence the local immune microenvironment. Our findings suggest a previously unrecognized link between dysbiosis and breast cancer which has potential diagnostic and therapeutic implications.Caiyun XuanJaime M ShamonkiAlice ChungMaggie L DinomeMaureen ChungPeter A SielingDelphine J LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e83744 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caiyun Xuan Jaime M Shamonki Alice Chung Maggie L Dinome Maureen Chung Peter A Sieling Delphine J Lee Microbial dysbiosis is associated with human breast cancer.
description	Breast cancer affects one in eight women in their lifetime. Though diet, age and genetic predisposition are established risk factors, the majority of breast cancers have unknown etiology. The human microbiota refers to the collection of microbes inhabiting the human body. Imbalance in microbial communities, or microbial dysbiosis, has been implicated in various human diseases including obesity, diabetes, and colon cancer. Therefore, we investigated the potential role of microbiota in breast cancer by next-generation sequencing using breast tumor tissue and paired normal adjacent tissue from the same patient. In a qualitative survey of the breast microbiota DNA, we found that the bacterium Methylobacterium radiotolerans is relatively enriched in tumor tissue, while the bacterium Sphingomonas yanoikuyae is relatively enriched in paired normal tissue. The relative abundances of these two bacterial species were inversely correlated in paired normal breast tissue but not in tumor tissue, indicating that dysbiosis is associated with breast cancer. Furthermore, the total bacterial DNA load was reduced in tumor versus paired normal and healthy breast tissue as determined by quantitative PCR. Interestingly, bacterial DNA load correlated inversely with advanced disease, a finding that could have broad implications in diagnosis and staging of breast cancer. Lastly, we observed lower basal levels of antibacterial response gene expression in tumor versus healthy breast tissue. Taken together, these data indicate that microbial DNA is present in the breast and that bacteria or their components may influence the local immune microenvironment. Our findings suggest a previously unrecognized link between dysbiosis and breast cancer which has potential diagnostic and therapeutic implications.
format	article
author	Caiyun Xuan Jaime M Shamonki Alice Chung Maggie L Dinome Maureen Chung Peter A Sieling Delphine J Lee
author_facet	Caiyun Xuan Jaime M Shamonki Alice Chung Maggie L Dinome Maureen Chung Peter A Sieling Delphine J Lee
author_sort	Caiyun Xuan
title	Microbial dysbiosis is associated with human breast cancer.
title_short	Microbial dysbiosis is associated with human breast cancer.
title_full	Microbial dysbiosis is associated with human breast cancer.
title_fullStr	Microbial dysbiosis is associated with human breast cancer.
title_full_unstemmed	Microbial dysbiosis is associated with human breast cancer.
title_sort	microbial dysbiosis is associated with human breast cancer.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/d84ba8bffe4343799788665adccf17bd
work_keys_str_mv	AT caiyunxuan microbialdysbiosisisassociatedwithhumanbreastcancer AT jaimemshamonki microbialdysbiosisisassociatedwithhumanbreastcancer AT alicechung microbialdysbiosisisassociatedwithhumanbreastcancer AT maggieldinome microbialdysbiosisisassociatedwithhumanbreastcancer AT maureenchung microbialdysbiosisisassociatedwithhumanbreastcancer AT peterasieling microbialdysbiosisisassociatedwithhumanbreastcancer AT delphinejlee microbialdysbiosisisassociatedwithhumanbreastcancer
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Microbial dysbiosis is associated with human breast cancer.

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